Cystoisospora canis Nemeseri, 1959 (Syn. Isospora canis), infections in dogs: Clinical signs, pathogenesis, and reproducible clinical disease in beagle dogs fed oocysts

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dc.contributor.authorMitchell, S. M.en
dc.contributor.authorZajac, Anne M.en
dc.contributor.authorCharles, S.en
dc.contributor.authorDuncan, R. B.en
dc.contributor.authorLindsay, David S.en
dc.date.accessed2014-06-16en
dc.date.accessioned2014-06-20T14:13:11Zen
dc.date.available2014-06-20T14:13:11Zen
dc.date.issued2007-04en
dc.description.abstractCanine intestinal coccidiosis is a cause of diarrhea in young dogs and dogs that are immunocompromised. Reports in the literature indicate that experimental reproduction of clinical coccidiosis with Cystoisospora canis (syn. Isospora canis) is difficult, and few studies have been done with C canis. Experimental oral infections were attempted in 22, 6- to 8-wk-old female beagles with 5 x 10(4) (n = 2) or 1 x 10(5) (n = 20) sporulated C. canis oocysts. Diarrhea was observed in all inoculated dogs. Diarrhea began 2-3 days before oocyst excretion. Five of the 22 dogs were given an anticoccidial (sulfadimethoxine) because of their clinical signs. The mean prepatent period was 9.8 days (range, 9-11 days, n = 22 dogs), and the patent period was 8.9 days (range, 7-18 days, n = 20 dogs). Two dogs exhibiting clinical coccidiosis were examined at necropsy 10 days after infection. Developmental stages of C canis were present in cells in the lamina propria throughout the entire small intestine in both dogs. Microscopic lesions observed in both of these dogs were villous atrophy, dilation of lacteals, and hyperplasia of lymph nodes in Peyer's patches. Results of bacterial and viral examinations of these 2 dogs were negative, indicating that intestinal coccidiosis was the cause of the diarrhea. Our study indicates that C. canis can be a primary cause of diarrhea in young dogs.en
dc.description.sponsorshipBayer HealthCare Animal Healthen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSheila M. Mitchell, Anne M. Zajac, Sam Charles, Robert B. Duncan, and David S. Lindsay (2007). "Cystoisospora canis Nemeseri, 1959 (Syn. Isospora canis), infections in dogs: Clinical signs, pathogenesis, and reproducible clinical disease in beagle dogs fed oocysts," Journal of Parasitology, Vol. 93, No. 2, pp. 345-352. doi: http://dx.doi.org/10.1645/GE-1024R.1en
dc.identifier.doihttps://doi.org/10.1645/ge-1024r.1en
dc.identifier.issn0022-3395en
dc.identifier.urihttp://hdl.handle.net/10919/49032en
dc.identifier.urlhttp://www.bioone.org/doi/abs/10.1645/GE-1024R.1en
dc.language.isoenen
dc.publisherAmerican Society of Parasitologyen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectcamel camelus-dromedariusen
dc.subjectlife-cycleen
dc.subjectcoccidian parasitesen
dc.subjectendogenousen
dc.subjectstagesen
dc.subjectsuis biesteren
dc.subjectsp-nen
dc.subjectohioensisen
dc.subjectrivoltaen
dc.subjectcoyotesen
dc.subjectmeaten
dc.subjectparasitologyen
dc.titleCystoisospora canis Nemeseri, 1959 (Syn. Isospora canis), infections in dogs: Clinical signs, pathogenesis, and reproducible clinical disease in beagle dogs fed oocystsen
dc.title.serialJournal of Parasitologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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