Dalbavancin as sequential therapy for infective endocarditis due to Gram-positive organisms: A review

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dc.contributor.authorFazili, Tasaduqen
dc.contributor.authorBansal, Ekta N.en
dc.contributor.authorGarner, Dorothyen
dc.contributor.authorGomez, Marianaen
dc.contributor.authorStornelli, Nicholasen
dc.date.accessioned2023-02-09T19:33:56Zen
dc.date.available2023-02-09T19:33:56Zen
dc.date.issued2023-02en
dc.date.updated2023-02-09T18:03:53Zen
dc.description.abstractDalbavancin is a parenteral lipoglycopeptide antibiotic derived from teicoplanin, an analog of vancomycin. It is mainly used for skin and soft tissue infections. The sustained half-life of around 14 days makes dalbavancin a novel option for potential use as sequential treatment in infections like infective endocarditis, which require prolonged antibiotic courses. However, only a few studies have been reported in the literature and its use remains limited. We reviewed the currently available literature using dalbavancin in the treatment of infective endocarditis due to Gram-positive organisms. Almost all patients received dalbavancin as sequential therapy following standard of care antibiotics. The overall clinical efficacy was around 90% and it appeared to be well tolerated.en
dc.description.versionAccepted versionen
dc.format.mimetypeapplication/pdfen
dc.identifier106749 (Article number)en
dc.identifier.doihttps://doi.org/10.1016/j.ijantimicag.2023.106749en
dc.identifier.issn0924-8579en
dc.identifier.orcidGomez, Mariana [0000-0001-8963-9959]en
dc.identifier.urihttp://hdl.handle.net/10919/113754en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.titleDalbavancin as sequential therapy for infective endocarditis due to Gram-positive organisms: A reviewen
dc.title.serialInternational Journal of Antimicrobial Agentsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Internal Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Internal Medicine/Infectious Diseaseen

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