Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer

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dc.contributor.authorLaramie, Matthew D.en
dc.contributor.authorFouts, Benjamin L.en
dc.contributor.authorMacCuaig, William M.en
dc.contributor.authorBuabeng, Emmanuelen
dc.contributor.authorJones, Meredith A.en
dc.contributor.authorMukherjee, Priyabrataen
dc.contributor.authorBehkam, Baharehen
dc.contributor.authorMcNally, Lacey R.en
dc.contributor.authorHenary, Mageden
dc.contributor.departmentMechanical Engineeringen
dc.date.accessioned2021-05-12T12:27:20Zen
dc.date.available2021-05-12T12:27:20Zen
dc.date.issued2021-02-23en
dc.description.abstractOptoacoustic imaging is a new biomedical imaging technology with clear benefits over traditional optical imaging and ultrasound. While the imaging technology has improved since its initial development, the creation of dedicated contrast agents for optoacoustic imaging has been stagnant. Current exploration of contrast agents has been limited to standard commercial dyes that have already been established in optical imaging applications. While some of these compounds have demonstrated utility in optoacoustic imaging, they are far from optimal and there is a need for contrast agents with tailored optoacoustic properties. The synthesis, encapsulation within tumor targeting silica nanoparticles and applications in in vivo tumor imaging of optoacoustic contrast agents are reported.en
dc.description.notesThis work was supported by grants to MH from the Brains and Behaviour Seed Grant, the Atlanta Clinical & Translational Science Institute for the Healthcare Innovation Program Grant and the Georgia Research Alliance for the Ventures Phase 1 Grant. LM would like to thank the NIH grants R01CA205941, R01CA212350, and R01EB020125 for the support.en
dc.description.sponsorshipBrains and Behaviour Seed Grant; Atlanta Clinical & Translational Science Institute for the Healthcare Innovation Program Grant; Georgia Research Alliance for the Ventures Phase 1 Grant; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01CA205941, R01CA212350, R01EB020125]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1038/s41598-021-83658-3en
dc.identifier.issn2045-2322en
dc.identifier.issue1en
dc.identifier.other4366en
dc.identifier.pmid33623069en
dc.identifier.urihttp://hdl.handle.net/10919/103252en
dc.identifier.volume11en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleImproved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic canceren
dc.title.serialScientific Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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