HIV-1 drug discovery: targeting folded RNA structures with branched peptides

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dc.contributor.authorWynn, Jessica E.en
dc.contributor.authorSantos, Webster L.en
dc.contributor.departmentChemistryen
dc.contributor.departmentCenter for Drug Discoveryen
dc.date.accessed2016-03-17en
dc.date.accessioned2016-03-18T22:24:56Zen
dc.date.available2016-03-18T22:24:56Zen
dc.date.issued2015-04-28en
dc.description.abstractHuman immunodeficiency virus type 1 (HIV-1) is an RNA virus that is prone to high rates of mutation. While the disease is managed with current antiretroviral therapies, drugs with a new mode of action are needed. A strategy towards this goal is aimed at targeting the native three-dimensional fold of conserved RNA structures. This perspective highlights medium-sized peptides and peptidomimetics used to target two conserved RNA structures of HIV-1. In particular, branched peptides have the capacity to bind in a multivalent fashion, utilizing a large surface area to achieve the necessary affinity and selectivity toward the target RNA.en
dc.description.notes2015 Royal Society of Chemistry Open Access Gold Articleen
dc.description.sponsorshipNational Institutes of Health (U.S.)en
dc.description.sponsorshipNational Institute of General Medical Sciences (U.S.)en
dc.format.extent11 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationWynn, J. E., & Santos, W. L. (2015). HIV-1 drug discovery: targeting folded RNA structures with branched peptides. Organic & Biomolecular Chemistry, 13(21), 5848-5858. doi:10.1039/C5OB00589Ben
dc.identifier.doihttps://doi.org/10.1039/C5OB00589Ben
dc.identifier.issn1477-0520en
dc.identifier.issue21en
dc.identifier.other2015_Wynn_HIV_1_drug_discovery_targeting_fold.pdfen
dc.identifier.otherGM093834en
dc.identifier.urihttp://hdl.handle.net/10919/64968en
dc.identifier.volume13en
dc.language.isoen_USen
dc.publisherThe Royal Society of Chemistryen
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unporteden
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/en
dc.titleHIV-1 drug discovery: targeting folded RNA structures with branched peptidesen
dc.title.serialOrganic & Biomolecular Chemistryen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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