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Genomic divergence and adaptive convergence in Drosophila simulans from Evolution Canyon, Israel

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dc.contributor.authorKang, Linen
dc.contributor.authorRashkovetsky, Eugeniaen
dc.contributor.authorMichalak, Katarzynaen
dc.contributor.authorGarner, Harold R.en
dc.contributor.authorMahaney, James E.en
dc.contributor.authorRzigalinski, Beverly A.en
dc.contributor.authorKorol, Abraham B.en
dc.contributor.authorNevo, Eviataren
dc.contributor.authorMichalak, Pawelen
dc.date.accessioned2019-08-23T16:37:20Zen
dc.date.available2019-08-23T16:37:20Zen
dc.date.issued2019-06-11en
dc.description.abstractBiodiversity refugia formed by unique features of the Mediterranean arid landscape, such as the dramatic ecological contrast of "Evolution Canyon," provide a natural laboratory in which local adaptations to divergent microclimate conditions can be investigated. Significant insights have been provided by studies of Drosophila melanogaster diversifying along the thermal gradient in Evolution Canyon, but a comparative framework to survey adaptive convergence across sister species at the site has been lacking. To fill this void, we present an analysis of genomic polymorphism and evolutionary divergence of Drosophila simulans, a close relative of Drosophila melanogaster with which it co-occurs on both slopes of the canyon. Our results show even deeper interslope divergence in D. simulans than in D. melanogaster, with extensive signatures of selective sweeps present in flies from both slopes but enhanced in the population from the hotter and drier south-facing slope. Interslope divergence was enriched for genes related to electrochemical balance and transmembrane transport, likely in response to increased selection for dehydration resistance on the hotter slope. Both species shared genomic regions that underwent major selective sweeps, but the overall level of adaptive convergence was low, demonstrating no shortage of alternative genomic solutions to cope with the challenges of the microclimate contrast. Mobile elements were a major source of genetic polymorphism and divergence, affecting all parts of the genome, including coding sequences of mating behavior-related genes.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1073/pnas.1720938116en
dc.identifier.issn0027-8424en
dc.identifier.issue24en
dc.identifier.pmid31127048en
dc.identifier.urihttp://hdl.handle.net/10919/93240en
dc.identifier.volume116en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectadaptive evolutionen
dc.subjectselective sweepsen
dc.subjectevolutionary convergenceen
dc.subjectlocal adaptationsen
dc.titleGenomic divergence and adaptive convergence in Drosophila simulans from Evolution Canyon, Israelen
dc.title.serialProceedings of the National Academy of Sciences of the United States of Americaen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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