Isolation and Synthesis of Bioactive Compounds from Plants

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dc.contributor.authorEaton, Alexander Leeen
dc.contributor.committeechairKingston, David G. I.en
dc.contributor.committeememberGandour, Richard D.en
dc.contributor.committeememberCarlier, Paul R.en
dc.contributor.committeememberSantos, Webster L.en
dc.contributor.departmentChemistryen
dc.date.accessioned2015-12-26T09:02:59Zen
dc.date.available2015-12-26T09:02:59Zen
dc.date.issued2015-12-09en
dc.description.abstractAs a part of a continuing search for bioactive compounds with the International Cooperative Biodiversity Group (ICBG), and in collaboration with the Natural Products Discovery Institute of the Institute for Hepatitis and Virus Research (IHVR), twelve plant extracts were investigated for their antiproliferative activity against the A2780 cell line, three plant extracts were investigated for their antimalarial activity against Plasmodium falciparum, and three plant extracts were investigated for their anti-inflammatory activity (PPAR-y inhibition). Bioassay-guided fractionation of extracts led to the identification of four new antiproliferative compounds (2.1-2.3, 3.1), five new anti-inflammatory compounds (6.4a, 6.5a-b, 6.6a, 6.6c), and twenty-eight known compounds from eight of the extracts. In addition, mallotojaponin C, an antimalarial natural product, and derivatives were synthesized and investigated for their antimalarial activity.en
dc.description.degreePh. D.en
dc.format.mediumETDen
dc.identifier.othervt_gsexam:6463en
dc.identifier.urihttp://hdl.handle.net/10919/64367en
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectNatural Productsen
dc.subjectAntiproliferativeen
dc.subjectAntimalarialen
dc.subjectAnti-inflammatoryen
dc.subjectTrihydroxyalkylcyclohexenonesen
dc.subjectDiterpeneen
dc.subjectTriterpeneen
dc.subjectBis-5-alkylresorcinolen
dc.subjectSynthesisen
dc.titleIsolation and Synthesis of Bioactive Compounds from Plantsen
dc.typeDissertationen
thesis.degree.disciplineChemistryen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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