Current and future impact of clinical gastrointestinal research on patient care in diabetes mellitus

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dc.contributor.authorKoch, Timothy R.en
dc.contributor.authorShope, Timothy R.en
dc.contributor.authorCamilleri, Michaelen
dc.date.accessioned2022-08-09T20:54:58Zen
dc.date.available2022-08-09T20:54:58Zen
dc.date.issued2018-11-15en
dc.date.updated2022-08-06T21:03:41Zen
dc.description.abstractThe worldwide rise in the prevalence of obesity supports the need for an increased interaction between ongoing clinical research in the allied fields of gastrointestinal medicine/surgery and diabetes mellitus. There have been a number of clinically-relevant advances in diabetes, obesity, and metabolic syndrome emanating from gastroenterological research. Gastric emptying is a significant factor in the development of upper gastrointestinal symptoms. However, it is not the only mechanism whereby such symptoms occur in patients with diabetes. Disorders of intrinsic pacing are involved in the control of stomach motility in patients with gastroparesis; on the other hand, there is limited impact of glycemic control on gastric emptying in patients with established diabetic gastroparesis. Upper gastrointestinal functions related to emptying and satiations are significantly associated with weight gain in obesity. Medications used in the treatment of diabetes or metabolic syndrome, particularly those related to pancreatic hormones and incretins affect upper gastrointestinal tract function and reduce hyperglycemia and facilitate weight loss. The degree of gastric emptying delay is significantly correlated with the weight loss in response to liraglutide, a glucagon-like peptide-1 analog. Network meta-analysis shows that liraglutide is one of the two most efficacious medical treatments of obesity, the other being the combination treatment phentermine-topiramate. Interventional therapies for the joint management of obesity and diabetes mellitus include newer endoscopic procedures, which require long-term follow-up and bariatric surgical procedure for which long-term follow up shows advantages for individuals with diabetes. Newer bariatric procedures are presently undergoing clinical evaluation. On the horizon, combination therapies, in part directed at gastrointestinal functions, appear promising for these indications. Ongoing and future gastroenterological research when translated to care of individuals with diabetes mellitus should provide additional options to improve their clinical outcomes.en
dc.description.versionPublished versionen
dc.format.extentPages 180-189en
dc.format.extent10 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.4239/wjd.v9.i11.180en
dc.identifier.eissn1948-9358en
dc.identifier.issn1948-9358en
dc.identifier.issue11en
dc.identifier.orcidKoch, Timothy [0000-0002-8026-9653]en
dc.identifier.urihttp://hdl.handle.net/10919/111497en
dc.identifier.volume9en
dc.language.isoenen
dc.publisherBaishidengen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000450661600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectObesityen
dc.subjectGastric emptyingen
dc.subjectDiabetes mellitusen
dc.subjectGastric bypassen
dc.subjectBariatric surgeryen
dc.subjectWeight lossen
dc.subjectLAPAROSCOPIC SLEEVE GASTRECTOMYen
dc.subjectENERGY-EXPENDITUREen
dc.subjectSINGLE-CENTERen
dc.subjectWEIGHT-LOSSen
dc.subjectASSOCIATIONen
dc.subjectGLP-1en
dc.subjectLIRAGLUTIDEen
dc.subjectDigestive Diseasesen
dc.subjectNutritionen
dc.subjectDiabetesen
dc.subjectPreventionen
dc.subjectMetabolic and endocrineen
dc.subjectCanceren
dc.subjectOral and gastrointestinalen
dc.subjectStrokeen
dc.titleCurrent and future impact of clinical gastrointestinal research on patient care in diabetes mellitusen
dc.title.serialWorld Journal of Diabetesen
dc.typeArticleen
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Internal Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Internal Medicine/General IMen

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