Delay of left ventricular longitudinal expansion with diastolic dysfunction: impact on load dependence of e′ and longitudinal strain rate

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dc.contributor.authorLwano, Hiroyukien
dc.contributor.authorPu, Minen
dc.contributor.authorUpadhya, Bharathien
dc.contributor.authorMeyers, Bretten
dc.contributor.authorVlachos, Pavlos P.en
dc.contributor.authorLittle, William C.en
dc.contributor.departmentMechanical Engineeringen
dc.date.accessioned2019-08-28T16:26:07Zen
dc.date.available2019-08-28T16:26:07Zen
dc.date.issued2014-07en
dc.description.abstractThe effect of diastolic dysfunction (DD) on the timing of left ventricular (LV) diastolic longitudinal and circumferential expansion and their load dependence is not known. This study evaluated the timing of the peak early diastolic LV inflow velocity (E), mitral annular velocity (e'), and longitudinal and circumferential global strain rates (SRE) in 161 patients in sinus rhythm. The intraventricular pressure difference (IVPD) from the left atrium to the LV apex was obtained using color M-mode Doppler data to integrate the Euler equation. The diastolic function was graded according to the guidelines. In normals (N = 57), E, e', longitudinal SRE, and circumferential SRE occurred nearly simultaneously during the IVPD. With DD (N = 104), e' and longitudinal SRE were delayed occurring after the IVPD (e': 18 +/- 23 msec, longitudinal SRE: 13 +/- 21 msec from the IVPD), whereas circumferential SRE (-8 +/- 28 msec) and E (-2 +/- 13 msec) were not delayed. The normal dependence of e' and longitudinal SRE on IVPD was reduced in DD; while the relation of circumferential SRE and E to IVPD were unchanged in DD. Thus, normally, the LV expands symmetrically during early diastole and both longitudinal and circumferential expansions are related to the IVPD. With DD, early diastolic longitudinal LV expansion is delayed, occurring after the IVPD and LV filling, resulting in their relative independence from the IVPD. In contrast, with DD, circumferential SRE and mitral inflow are not delayed and their normal relation to the IVPD is unchanged.en
dc.description.notesThis study is partially funded by NIH grant 7R21HL106276.03.en
dc.description.sponsorshipNIH [7R21HL106276.03]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.14814/phy2.12082en
dc.identifier.issn2051-817Xen
dc.identifier.issue7en
dc.identifier.othere12082en
dc.identifier.pmid25035279en
dc.identifier.urihttp://hdl.handle.net/10919/93284en
dc.identifier.volume2en
dc.language.isoenen
dc.publisherThe Physiological Societyen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectEchocardiographyen
dc.subjectheart failureen
dc.subjectintra left ventricular pressure differenceen
dc.subjectleft ventricular diastolic functionen
dc.titleDelay of left ventricular longitudinal expansion with diastolic dysfunction: impact on load dependence of e′ and longitudinal strain rateen
dc.title.serialPhysiological Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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