Molecular Adaptations for Sensing and Securing Prey and Insight into Amniote Genome Diversity from the Garter Snake Genome

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dc.contributor.authorPerry, Blair W.en
dc.contributor.authorCard, Daren C.en
dc.contributor.authorMcGlothlin, Joel W.en
dc.contributor.authorPasquesi, Giulia IM M.en
dc.contributor.authorAdams, Richard H.en
dc.contributor.authorSchield, Drew R.en
dc.contributor.authorHales, Nicole R.en
dc.contributor.authorCorbin, Andrew B.en
dc.contributor.authorDemuth, Jeffery P.en
dc.contributor.authorHoffmann, Federico G.en
dc.contributor.authorVandewege, Michael W.en
dc.contributor.authorSchott, Ryan K.en
dc.contributor.authorBhattacharyya, Niharen
dc.contributor.authorChang, Belinda SW W.en
dc.contributor.authorCasewell, Nicholas R.en
dc.contributor.authorWhiteley, Garethen
dc.contributor.authorReyes-Velasco, Jacoboen
dc.contributor.authorMackessy, Stephen P.en
dc.contributor.authorGamble, Tonyen
dc.contributor.authorStorey, Kenneth B.en
dc.contributor.authorBiggar, Kyle K.en
dc.contributor.authorPassow, Courtney N.en
dc.contributor.authorKuo, Chih-Horngen
dc.contributor.authorMcGaugh, Suzanne E.en
dc.contributor.authorBronikowski, Anne M.en
dc.contributor.authorde Koning, AP Jason P. J.en
dc.contributor.authorEdwards, Scott V.en
dc.contributor.authorPfrender, Michael E.en
dc.contributor.authorMinx, Patricken
dc.contributor.authorBrodie, Edmund D.en
dc.contributor.authorBrodie, Edmund D.en
dc.contributor.authorWarren, Wesley C.en
dc.contributor.authorCastoe, Todd A.en
dc.date.accessioned2021-11-03T14:04:48Zen
dc.date.available2021-11-03T14:04:48Zen
dc.date.issued2018-08-01en
dc.date.updated2021-11-03T14:04:44Zen
dc.description.abstractColubridae represents themost phenotypically diverse and speciose family of snakes, yet nowell-assembled and annotated genome exists for this lineage. Here, we report and analyze the genome of the garter snake, Thamnophis sirtalis, a colubrid snake that is an important model species for research in evolutionary biology, physiology, genomics, behavior, and the evolution of toxin resistance. Using the garter snake genome, we show how snakes have evolved numerous adaptations for sensing and securing prey, and identify features of snake genomestructure that provide insight into the evolution of amniote genomes.Analyses of the garter snake andother squamate reptile genomes highlight shifts in repeat element abundance andexpansionwithin snakes, uncover evidence of genes under positive selection, and provide revised neutral substitution rate estimates for squamates. Our identification of Z andW sex chromosome-specific scaffolds provides evidence for multiple origins of sex chromosome systems in snakes and demonstrates the value of this genome for studying sex chromosome evolution. Analysis of gene duplication and loss in visual and olfactory gene families supports a dim-light ancestral condition in snakes and indicates that olfactory receptor repertoires underwent an expansion early in snake evolution. Additionally, we provide some of the first links between secreted venom proteins, the genes that encode them, and their evolutionaryorigins ina rear-fanged colubridsnake, togetherwith newgenomic insight into the coevolutionary arms race between garter snakes and highly toxic newt prey that led to toxin resistance in garter snakes.en
dc.description.versionPublished versionen
dc.format.extentPages 2110-2129en
dc.format.extent20 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1093/gbe/evy157en
dc.identifier.eissn1759-6653en
dc.identifier.issn1759-6653en
dc.identifier.issue8en
dc.identifier.orcidMcGlothlin, Joel [0000-0003-3645-6264]en
dc.identifier.other5061318 (PII)en
dc.identifier.pmid30060036en
dc.identifier.urihttp://hdl.handle.net/10919/106499en
dc.identifier.volume10en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000444553900022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectLife Sciences & Biomedicineen
dc.subjectEvolutionary Biologyen
dc.subjectGenetics & Heredityen
dc.subjectThamnophis sirtalisen
dc.subjectco-evolutionen
dc.subjectvenomen
dc.subjectvisionen
dc.subjectsex chromosomesen
dc.subjectRESISTANT SODIUM-CHANNELSen
dc.subjectTHAMNOPHIS-SIRTALISen
dc.subjectTETRODOTOXIN RESISTANCEen
dc.subjectEVOLUTIONARY DIVERSIFICATIONen
dc.subjectPHYLOGENETIC ANALYSISen
dc.subjectADAPTIVE EVOLUTIONen
dc.subjectCOURTSHIP BEHAVIORen
dc.subjectVISUAL PIGMENTSen
dc.subjectSEX-CHROMOSOMESen
dc.subjectBINDING-SITEen
dc.subject0601 Biochemistry and Cell Biologyen
dc.subject0603 Evolutionary Biologyen
dc.subject0604 Geneticsen
dc.subjectDevelopmental Biologyen
dc.subject.meshVenomsen
dc.subject.meshAnimalsen
dc.subject.meshReptilesen
dc.subject.meshSnakesen
dc.subject.meshRetinal Pigmentsen
dc.subject.meshReceptors, Odoranten
dc.subject.meshPredatory Behavioren
dc.subject.meshAdaptation, Physiologicalen
dc.subject.meshEvolution, Molecularen
dc.subject.meshGenomeen
dc.subject.meshFemaleen
dc.subject.meshPhotoreceptor Cells, Vertebrateen
dc.subject.meshSelection, Geneticen
dc.subject.meshMolecular Sequence Annotationen
dc.subject.meshVoltage-Gated Sodium Channelsen
dc.titleMolecular Adaptations for Sensing and Securing Prey and Insight into Amniote Genome Diversity from the Garter Snake Genomeen
dc.title.serialGenome Biology and Evolutionen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2018-07-26en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/Biological Sciencesen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Durelle Scotten

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