Delivery strategies for cell-based therapies in the brain: overcoming multiple barriers

Simple item page
dc.contributor.authorTurk, Olivia M.en
dc.contributor.authorWoodall, Ryan C.en
dc.contributor.authorGutova, Margaritaen
dc.contributor.authorBrown, Christine E.en
dc.contributor.authorRockne, Russell C.en
dc.contributor.authorMunson, Jennifer M.en
dc.date.accessioned2022-01-27T14:01:57Zen
dc.date.available2022-01-27T14:01:57Zen
dc.date.issued2021-10-30en
dc.date.updated2022-01-27T13:43:16Zen
dc.description.abstractCell-based therapies to the brain are promising for the treatment of multiple brain disorders including neurodegeneration and cancers. In order to access the brain parenchyma, there are multiple physiological barriers that must be overcome depending on the route of delivery. Specifically, the blood–brain barrier has been a major difficulty in drug delivery for decades, and it still presents a challenge for the delivery of therapeutic cells. Other barriers, including the blood-cerebrospinal fluid barrier and lymphatic-brain barrier, are less explored, but may offer specific challenges or opportunities for therapeutic delivery. Here we discuss the barriers to the brain and the strategies currently in place to deliver cell-based therapies, including engineered T cells, dendritic cells, and stem cells, to treat diseases. With a particular focus on cancers, we also highlight the current ongoing clinical trials that use cell-based therapies to treat disease, many of which show promise at treating some of the deadliest illnesses. Graphical abstract: [Figure not available: see fulltext.].en
dc.description.versionAccepted versionen
dc.format.extentPages 2448-2467en
dc.format.extent20 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1007/s13346-021-01079-1en
dc.identifier.eissn2190-3948en
dc.identifier.issn2190-393Xen
dc.identifier.issue6en
dc.identifier.orcidMunson, Jennifer [0000-0002-9477-1505]en
dc.identifier.other10.1007/s13346-021-01079-1 (PII)en
dc.identifier.pmid34718958en
dc.identifier.urihttp://hdl.handle.net/10919/107950en
dc.identifier.volume11en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000712933700002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectTechnologyen
dc.subjectLife Sciences & Biomedicineen
dc.subjectInstruments & Instrumentationen
dc.subjectMedicine, Research & Experimentalen
dc.subjectPharmacology & Pharmacyen
dc.subjectResearch & Experimental Medicineen
dc.subjectBrainen
dc.subjectCanceren
dc.subjectT cellsen
dc.subjectDrug deliveryen
dc.subjectBlood-brain barrieren
dc.subjectNeural stem cellsen
dc.subjectCONVECTION-ENHANCED DELIVERYen
dc.subjectRECEPTOR T-CELLSen
dc.subjectDENDRITIC CELLSen
dc.subjectFOCUSED ULTRASOUNDen
dc.subjectSIPULEUCEL-Ten
dc.subjectMALIGNANT GLIOMAen
dc.subjectDRUG-DELIVERYen
dc.subjectNK-92 CELLSen
dc.subjectSTEMen
dc.subjectTUMORSen
dc.subject1115 Pharmacology and Pharmaceutical Sciencesen
dc.titleDelivery strategies for cell-based therapies in the brain: overcoming multiple barriersen
dc.title.serialDrug Delivery and Translational Researchen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2021-10-04en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2021_Turk et al._DDTR.pdf
Size:
2.43 MB
Format:
Adobe Portable Document Format
Description:
Accepted version
Download

Collections

All Faculty Deposits
Destination Area: Adaptive Brain and Behavior (ABB)
Scholarly Works, Fralin Biomedical Research Institute at VTC