Management Options for Reducing the Release of Antibiotics and Antibiotic Resistance Genes to the Environment

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dc.contributor.authorPruden, Amyen
dc.contributor.authorLarsson, D. G. J.en
dc.contributor.authorAmezquita, A.en
dc.contributor.authorCollignon, P.en
dc.contributor.authorBrandt, K. K.en
dc.contributor.authorGraham, D. W.en
dc.contributor.authorLazorchak, J. M.en
dc.contributor.authorSuzuki, Shinen
dc.contributor.authorSilley, P.en
dc.contributor.authorSnape, J. R.en
dc.contributor.authorTopp, E.en
dc.contributor.authorZhang, T.en
dc.contributor.authorZhu, Y.-G.en
dc.contributor.departmentCivil and Environmental Engineeringen
dc.date.accessioned2017-03-07T16:14:14Zen
dc.date.available2017-03-07T16:14:14Zen
dc.date.issued2013-08-01en
dc.description.abstractBackground: There is growing concern worldwide about the role of polluted soil and water environments in the development and dissemination of antibiotic resistance. Objective: Our aim in this study was to identify management options for reducing the spread of antibiotics and antibiotic-resistance determinants via environmental pathways, with the ultimate goal of extending the useful life span of antibiotics. We also examined incentives and disincentives for action. Methods: We focused on management options with respect to limiting agricultural sources; treatment of domestic, hospital, and industrial wastewater; and aquaculture. Discussion: We identified several options, such as nutrient management, runoff control, and infrastructure upgrades. Where appropriate, a cross-section of examples from various regions of the world is provided. The importance of monitoring and validating effectiveness of management strategies is also highlighted. Finally, we describe a case study in Sweden that illustrates the critical role of communication to engage stakeholders and promote action. Conclusions: Environmental releases of antibiotics and antibiotic-resistant bacteria can in many cases be reduced at little or no cost. Some management options are synergistic with existing policies and goals. The anticipated benefit is an extended useful life span for current and future antibiotics. Although risk reductions are often difficult to quantify, the severity of accelerating worldwide morbidity and mortality rates associated with antibiotic resistance strongly indicate the need for action.en
dc.description.versionPublished versionen
dc.format.extent878 - 885 (8) page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1289/ehp.1206446en
dc.identifier.issn0091-6765en
dc.identifier.issue8en
dc.identifier.urihttp://hdl.handle.net/10919/75299en
dc.identifier.volume121en
dc.language.isoenen
dc.publisherUs Dept Health Human Sciences Public Health Scienceen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000323711700013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectEnvironmental Sciencesen
dc.subjectPublic, Environmental & Occupational Healthen
dc.subjectToxicologyen
dc.subjectEnvironmental Sciences & Ecologyen
dc.subjectPUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH, SCIen
dc.subjectagricultureen
dc.subjectantibiotic manufacturingen
dc.subjectantibiotic resistanceen
dc.subjectaquacultureen
dc.subjectlivestocken
dc.subjectmanure managementen
dc.subjectpolicyen
dc.subjectwastewater treatmenten
dc.subjectWASTE-WATER TREATMENTen
dc.subjectTETRACYCLINE RESISTANCEen
dc.subjectANTIMICROBIAL RESISTANCEen
dc.subjectTREATMENT PLANTSen
dc.subjectESCHERICHIA-COLIen
dc.subjectACTIVATED-SLUDGEen
dc.subjectLAND APPLICATIONen
dc.subjectHUMAN HEALTHen
dc.subjectBACTERIAen
dc.subjectAQUACULTUREen
dc.titleManagement Options for Reducing the Release of Antibiotics and Antibiotic Resistance Genes to the Environmenten
dc.title.serialEnvironmental Health Perspectivesen
dc.typeArticle - Refereeden
dc.typeReviewen
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Engineeringen
pubs.organisational-group/Virginia Tech/Engineering/Civil & Environmental Engineeringen
pubs.organisational-group/Virginia Tech/Engineering/COE T&R Facultyen

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