A case of stiff dog syndrome associated with anti-glutamic acid decarboxylase antibodies
| dc.contributor.author | Pancotto, Theresa E. | en |
| dc.contributor.author | Rossmeisl, John H. Jr. | en |
| dc.date.accessioned | 2017-08-03T20:16:04Z | en |
| dc.date.available | 2017-08-03T20:16:04Z | en |
| dc.date.issued | 2017-05-10 | en |
| dc.date.updated | 2017-08-03T11:00:55Z | en |
| dc.description.abstract | Background The stiff person syndrome (SPS) is a rare and debilitating autoimmune disorder with an unknown pathogenesis and variable clinical presentation that can present a diagnostic challenge. Although entities that clinically mimic stiff-person spectrum disorders (SPSD) have manifested in horses, they have not been reported in dogs. Case presentation We describe a 2-year-old beagle dog presented for progressive attacks of muscular rigidity and lordosis with superimposed spasms of the appendicular muscles triggered by tactile stimulation which resulted in marked gait impairment. Resting electromyography revealed continuous motor unit activity in the axial musculature. Compared to age-matched healthy beagle dogs, this patient had elevated glutamic acid decarboxylase antibody concentrations in serum and cerebrospinal fluid. Conclusions This dog presented with phenotypic, electrodiagnostic, and immunologic criterion consistent with an SPSD, including elevated anti-GAD antibody titers, which we have termed the “stiff dog syndrome (SDS)”. Durable clinical improvement was achieved with symptomatic and immunosuppressive treatments including baclofen, gabapentin, prednisone, and intravenous immunoglobulin. | en |
| dc.description.version | Published version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Journal of Clinical Movement Disorders. 2017 May 10;4(1):5 | en |
| dc.identifier.doi | https://doi.org/10.1186/s40734-017-0053-3 | en |
| dc.identifier.uri | http://hdl.handle.net/10919/78663 | en |
| dc.language.iso | en | en |
| dc.rights | Creative Commons Attribution 4.0 International | en |
| dc.rights.holder | The Author(s) | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
| dc.title | A case of stiff dog syndrome associated with anti-glutamic acid decarboxylase antibodies | en |
| dc.title.serial | Journal of Clinical Movement Disorders | en |
| dc.type | Article - Refereed | en |
| dc.type.dcmitype | Text | en |