Neural correlates of working memory training: Evidence for plasticity in older adults

Simple item page
dc.contributor.authorIordan, Alexandru D.en
dc.contributor.authorCooke, Katherine A.en
dc.contributor.authorMoored, Kyle D.en
dc.contributor.authorKatz, Benjaminen
dc.contributor.authorBuschkuehl, Martinen
dc.contributor.authorJaeggi, Susanne M.en
dc.contributor.authorPolk, Thad A.en
dc.contributor.authorPeltier, Scott J.en
dc.contributor.authorJonides, Johnen
dc.contributor.authorReuter-Lorenz, Patricia A.en
dc.contributor.departmentHuman Development and Family Scienceen
dc.date.accessioned2020-07-27T19:41:36Zen
dc.date.available2020-07-27T19:41:36Zen
dc.date.issued2020-08-15en
dc.description.abstractBrain activity typically increases with increasing working memory (WM) load, regardless of age, before reaching an apparent ceiling. However, older adults exhibit greater brain activity and reach ceiling at lower loads than younger adults, possibly reflecting compensation at lower loads and dysfunction at higher loads. We hypothesized that WM training would bolster neural efficiency, such that the activation peak would shift towards higher memory loads after training. Pre-training, older adults showed greater recruitment of the WM network than younger adults across all loads, with decline at the highest load. Ten days of adaptive training on a verbal WM task improved performance and led to greater brain responsiveness at higher loads for both groups. For older adults the activation peak shifted rightward towards higher loads. Finally, training increased task-related functional connectivity in older adults, both within the WM network and between this task-positive network and the task-negative/default-mode network. These results provide new evidence for functional plasticity with training in older adults and identify a potential signature of improvement at the neural level.en
dc.description.notesThis research was supported by a National Institute on Aging [R21-AG-045460] grant to P.A.R.-L. and a National Institutes of Health [1S10OD012240-01A1] grant. The authors thank Krisanne Litinas for assistance with MRI data reconstruction and Daniel Weissman for comments on a previous version of the manuscript.en
dc.description.sponsorshipNational Institute on AgingUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [R21-AG-045460]; National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [1S10OD012240-01A1]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.neuroimage.2020.116887en
dc.identifier.eissn1095-9572en
dc.identifier.issn1053-8119en
dc.identifier.other116887en
dc.identifier.pmid32376302en
dc.identifier.urihttp://hdl.handle.net/10919/99438en
dc.identifier.volume217en
dc.language.isoenen
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.titleNeural correlates of working memory training: Evidence for plasticity in older adultsen
dc.title.serialNeuroimageen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1-s2.0-S1053811920303736-main.pdf
Size:
1.74 MB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Scholarly Works, Human Development and Family Science
Destination Area: Adaptive Brain and Behavior (ABB)