Dietary Flavonoids in the Prevention of T2D: An Overview

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dc.contributor.authorAlkhalidy, Hanaen
dc.contributor.authorWang, Yaoen
dc.contributor.authorLiu, Dongminen
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2018-04-25T17:18:54Zen
dc.date.available2018-04-25T17:18:54Zen
dc.date.issued2018-03-31en
dc.date.updated2018-04-25T15:19:04Zen
dc.description.abstractType 2 diabetes (T2D) is a progressive metabolic disease that is increasing in prevalence globally. It is well established that insulin resistance (IR) and a progressive decline in functional β-cell mass are hallmarks of developing T2D. Obesity is a leading pathogenic factor for developing IR. Constant IR will progress to T2D when β-cells are unable to secret adequate amounts of insulin to compensate for decreased insulin sensitivity. Recently, a considerable amount of research has been devoted to identifying naturally occurring anti-diabetic compounds that are abundant in certain types of foods. Flavonoids are a group of polyphenols that have drawn great interest for their various health benefits. Results from many clinical and animal studies demonstrate that dietary intake of flavonoids might be helpful in preventing T2D, although cellular and molecular mechanisms underlying these effects are still not completely understood. This review discusses our current understanding of the pathophysiology of T2D and highlights the potential anti-diabetic effects of flavonoids and mechanisms of their actions.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAlkhalidy, H.; Wang, Y.; Liu, D. Dietary Flavonoids in the Prevention of T2D: An Overview. Nutrients 2018, 10, 438.en
dc.identifier.doihttps://doi.org/10.3390/nu10040438en
dc.identifier.urihttp://hdl.handle.net/10919/82916en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectflavonoidsen
dc.subjecttype 2 diabetesen
dc.subjectinsulin resistanceen
dc.titleDietary Flavonoids in the Prevention of T2D: An Overviewen
dc.title.serialNutrientsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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