Brucella abortus RB51 ΔleuB expressing Salmonella FliC conjugated gonadotropins reduces mouse fetal numbers: A possible feral swine brucellosis immunocontraceptive vaccine

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dc.contributor.authorWaldrop, Steven Granten
dc.contributor.authorSmith, Garrett P.en
dc.contributor.authorBoyle, Stephen M.en
dc.contributor.authorSriranganathan, Nammalwaren
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.date.accessioned2021-05-24T14:24:11Zen
dc.date.available2021-05-24T14:24:11Zen
dc.date.issued2021-02en
dc.description.abstractPopulation and health management of wildlife is a key to environmental health, domestic herd health, and ultimately public health. Many different methods including: surgical sterilization, poison baits, and sponsored hunting programs have been used in the attempt to control populations of various nuisance animal species. Particular interest has been given to immunocontraception through wildlife vaccination protocols. This study specifically looked at the potential immunocontraceptive and protective properties of a Brucella abortus RB51 Delta leuB vaccine expressing Salmonella typhimurium FliC conjugated to porcine follicle stimulating hormone beta subunit (FSH beta) or gonadotropin releasing hormone (GnRH) DNA sequences. B. abortus RB51 Delta leuB pNS4-TrcD-FliC-FSH beta (RB51LFSH beta) and B. abortus RB51 Delta leuB pNS4-TrcD-FliC-GnRH (RB51LGnRH) were tested in a pilot breeding study with BALB/c mice, and a significant reduction in fertility characteristics was observed in both male and female mice. Ultimately, this study provides support to test these vaccine candidates in feral swine, a destructive invasive species in the United States of America.en
dc.description.notesThis work was supported by Smithfield Foods Murphy-Brown, LLC (Virginia Tech Foundation, Inc. Fund #444115) , and the Virginia Maryland College of Veterinary Medicine's Office of Research and Graduate Studies.en
dc.description.sponsorshipSmithfield Foods Murphy-Brown, LLC (Virginia Tech Foundation, Inc.) [444115]; Virginia Maryland College of Veterinary Medicine's Office of Research and Graduate Studiesen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.heliyon.2021.e06149en
dc.identifier.issn2405-8440en
dc.identifier.issue2en
dc.identifier.othere06149en
dc.identifier.pmid33644455en
dc.identifier.urihttp://hdl.handle.net/10919/103454en
dc.identifier.volume7en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectFertility controlen
dc.subjectFeral swineen
dc.subjectFSH beta/GnRHen
dc.subjectBrucellaen
dc.subjectRB51en
dc.subjectSalmonellaen
dc.subjectFeral swine population controlen
dc.titleBrucella abortus RB51 ΔleuB expressing Salmonella FliC conjugated gonadotropins reduces mouse fetal numbers: A possible feral swine brucellosis immunocontraceptive vaccineen
dc.title.serialHeliyonen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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Scholarly Works, Biomedical Sciences and Pathobiology
Destination Area: Global Systems Science (GSS)