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Electroresponsive Hydrogels for Therapeutic Applications in the Brain

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dc.contributor.authorKhan, Zerin Mahzabinen
dc.contributor.authorWilts, Emilyen
dc.contributor.authorVlaisavljevich, Elien
dc.contributor.authorLong, Timothy E.en
dc.contributor.authorVerbridge, Scott S.en
dc.date.accessioned2022-02-05T19:34:49Zen
dc.date.available2022-02-05T19:34:49Zen
dc.date.issued2021-12-01en
dc.date.updated2022-02-05T19:34:45Zen
dc.description.abstractElectroresponsive hydrogels possess a conducting material component and respond to electric stimulation through reversible absorption and expulsion of water. The high level of hydration, soft elastomeric compliance, biocompatibility, and enhanced electrochemical properties render these hydrogels suitable for implantation in the brain to enhance the transmission of neural electric signals and ion transport. This review provides an overview of critical electroresponsive hydrogel properties for augmenting electric stimulation in the brain. A background on electric stimulation in the brain through electroresponsive hydrogels is provided. Common conducting materials and general techniques to integrate them into hydrogels are briefly discussed. This review focuses on and summarizes advances in electric stimulation of electroconductive hydrogels for therapeutic applications in the brain, such as for controlling delivery of drugs, directing neural stem cell differentiation and neurogenesis, improving neural biosensor capabilities, and enhancing neural electrode-tissue interfaces. The key challenges in each of these applications are discussed and recommendations for future research are also provided.en
dc.description.versionAccepted versionen
dc.format.extent36 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifierARTN 2100355 (Article number)en
dc.identifier.doihttps://doi.org/10.1002/mabi.202100355en
dc.identifier.eissn1616-5195en
dc.identifier.issn1616-5187en
dc.identifier.orcidVerbridge, Scott [0000-0002-4074-8799]en
dc.identifier.pmid34800348en
dc.identifier.urihttp://hdl.handle.net/10919/108148en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000724117400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectLife Sciences & Biomedicineen
dc.subjectTechnologyen
dc.subjectPhysical Sciencesen
dc.subjectBiochemistry & Molecular Biologyen
dc.subjectMaterials Science, Biomaterialsen
dc.subjectPolymer Scienceen
dc.subjectMaterials Scienceen
dc.subjectbiosensorsen
dc.subjectcontrolled deliveryen
dc.subjectelectroconductive hydrogelsen
dc.subjectneural electrode interfaceen
dc.subjectneural stem cell differentiationen
dc.subjectMESENCHYMAL STEM-CELLSen
dc.subjectCONDUCTING POLYMER HYDROGELen
dc.subjectELECTRICAL-STIMULATIONen
dc.subjectIN-VIVOen
dc.subjectCARBON NANOTUBEen
dc.subjectDRUG-DELIVERYen
dc.subjectNEURAL DIFFERENTIATIONen
dc.subjectMICROELECTRODE ARRAYSen
dc.subjectSURFACE MODIFICATIONen
dc.subjectBIOACTIVE MOLECULESen
dc.subjectPolymersen
dc.subject0303 Macromolecular and Materials Chemistryen
dc.subject0903 Biomedical Engineeringen
dc.subject0904 Chemical Engineeringen
dc.titleElectroresponsive Hydrogels for Therapeutic Applications in the Brainen
dc.title.serialMacromolecular Bioscienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherEarly Accessen
dc.type.otherJournalen
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Engineeringen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciencesen
pubs.organisational-group/Virginia Tech/Engineering/Biomedical Engineering and Mechanicsen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Engineering/COE T&R Facultyen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Durelle Scotten
pubs.organisational-group/Virginia Tech/Graduate studentsen
pubs.organisational-group/Virginia Tech/Graduate students/Doctoral studentsen

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