Statistical Analysis of Gene Expression Profile: Transcription Network Inference and Sample Classification

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dc.contributor.authorBing, Nanen
dc.contributor.committeechairHoeschele, Inaen
dc.contributor.committeememberYe, Keyingen
dc.contributor.committeememberRamakrishnan, Narenen
dc.contributor.committeememberMendes, Pedro J. P.en
dc.contributor.committeememberSaghai-Maroof, Mohammad A.en
dc.contributor.departmentGenetics, Bioinformatics, and Computational Biologyen
dc.date.accessioned2011-08-22T19:00:19Zen
dc.date.adate2004-04-21en
dc.date.available2011-08-22T19:00:19Zen
dc.date.issued2004-04-14en
dc.date.rdate2004-04-21en
dc.date.sdate2004-04-19en
dc.description.abstractThe copious information generated from transcriptomes gives us an opportunity to learn biological processes as integrated systems; however, due to numerous sources of variation, high dimensions of data structure, various levels of data quality, and different formats of the inputs, dissecting and interpreting such data presents daunting challenges to scientists. The goal of this research is to provide improved and new statistical tools for analyzing transcriptomes data to identify gene expression patterns for classifying samples, to discover regulatory gene networks using natural genetic perturbations, to develop statistical methods for model fitting and comparison of biochemical networks, and eventually to advance our capability to understand the principles of biological processes at the system level.en
dc.description.degreePh. D.en
dc.format.mediumETDen
dc.identifier.otheretd-04192004-011825en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-04192004-011825en
dc.identifier.urihttp://hdl.handle.net/10919/11139en
dc.publisherVirginia Techen
dc.relation.haspartThesis.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectStructural Equation Modelen
dc.subjectClassificationen
dc.subjectMixture Modelen
dc.subjectGene Networken
dc.subjectGenetical Genomicsen
dc.subjectMicroarrayen
dc.titleStatistical Analysis of Gene Expression Profile: Transcription Network Inference and Sample Classificationen
dc.typeDissertationen
thesis.degree.disciplineGenetics, Bioinformatics, and Computational Biologyen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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