Habitual daily intake of a sweet and fatty snack modulates reward processing in humans

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dc.contributor.authorThanarajah, Sharmili Edwinen
dc.contributor.authorDiFeliceantonio, Alexandra G.en
dc.contributor.authorAlbus, Kerstinen
dc.contributor.authorKuzmanovic, Bojanaen
dc.contributor.authorRigoux, Lionelen
dc.contributor.authorIglesias, Sandraen
dc.contributor.authorHanßen, Ruthen
dc.contributor.authorSchlamann, Marcen
dc.contributor.authorCornely, Oliver A.en
dc.contributor.authorBrüning, Jens C.en
dc.contributor.authorTittgemeyer, Marcen
dc.contributor.authorSmall, Dana M.en
dc.date.accessioned2023-04-24T11:57:03Zen
dc.date.available2023-04-24T11:57:03Zen
dc.date.issued2023-04-04en
dc.date.updated2023-04-21T16:44:59Zen
dc.description.abstractWestern diets rich in fat and sugar promote excess calorie intake and weight gain; however, the underlying mechanisms are unclear. Despite a well-documented association between obesity and altered brain dopamine function, it remains elusive whether these alterations are (1) pre-existing, increasing the individual susceptibility to weight gain, (2) secondary to obesity, or (3) directly attributable to repeated exposure to western diet. To close this gap, we performed a randomized, controlled study (NCT05574660) with normal-weight participants exposed to a high-fat/high-sugar snack or a low-fat/low-sugar snack for 8 weeks in addition to their regular diet. The high-fat/high-sugar intervention decreased the preference for low-fat food while increasing brain response to food and associative learning independent of food cues or reward. These alterations were independent of changes in body weight and metabolic parameters, indicating a direct effect of high-fat, high-sugar foods on neurobehavioral adaptations that may increase the risk for overeating and weight gain.en
dc.description.versionPublished versionen
dc.format.extentPages 571-584en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.cmet.2023.02.015en
dc.identifier.eissn1932-7420en
dc.identifier.issn1550-4131en
dc.identifier.issue4en
dc.identifier.orcidDiFeliceantonio, Alexandra [0000-0002-7155-6060]en
dc.identifier.otherS1550-4131(23)00051-7 (PII)en
dc.identifier.pmid36958330en
dc.identifier.urihttp://hdl.handle.net/10919/114751en
dc.identifier.volume35en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/36958330en
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectdopamineen
dc.subjectfMRIen
dc.subjecthigh-fat dieten
dc.subjectneural plasticityen
dc.subjectobesityen
dc.subjectprediction erroren
dc.subjectpreferenceen
dc.subjectreinforcement learningen
dc.subjectrewarden
dc.subjecttasteen
dc.subjectvalueen
dc.subject.meshHumansen
dc.subject.meshObesityen
dc.subject.meshWeight Gainen
dc.subject.meshRewarden
dc.subject.meshSnacksen
dc.subject.meshSugarsen
dc.titleHabitual daily intake of a sweet and fatty snack modulates reward processing in humansen
dc.title.serialCell Metabolismen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherJournal Articleen
dcterms.dateAccepted2023-02-23en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Biomedical Research Institute at VTCen

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