Evaluation of ifosfamide salvage therapy formetastatic canine osteosarcoma

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dc.contributor.authorBatschinski, K.en
dc.contributor.authorDervisis, Nikolaos G.en
dc.contributor.authorKitchell, Barbara E.en
dc.date.accessioned2016-11-15T20:48:20Zen
dc.date.available2016-11-15T20:48:20Zen
dc.date.issued2014-12-01en
dc.description.abstractA retrospective study was performed to assess toxicity and response rate of ifosfamide salvage treatment for dogs diagnosed with metastatic osteosarcoma (OSA). Dogs diagnosed with OSA and previously treated with standard chemotherapy were included in the study. Nineteen dogs met the inclusion criteria, and 17 dogs were evaluable for response. Ifosfamide doses ranged from 375 to 425 mg m−<sup>2</sup> (median dose 375 mg m−<sup>2</sup>), with a median of two doses administered per dog (range 1–7 doses). The overall response to ifosfamide was 11.8% [complete response (CR)=1/17, partial response (PR)=1/17, stable disease (SD)=2/17, progressive disease (PD)=13/17]. Two dogs were hospitalized due to ifosfamide toxicosis. The median survival duration from the first dose of ifosfamide to death was 95 days. Ifosfamide was well tolerated, but minor anti-tumour activity was observed.en
dc.description.versionPublished versionen
dc.format.extent249 - 257 (9) page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/j.1476-5829.2012.00355.xen
dc.identifier.issn1476-5810en
dc.identifier.issue4en
dc.identifier.urihttp://hdl.handle.net/10919/73452en
dc.identifier.volume12en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000345620000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectVeterinary Sciencesen
dc.subjectcanineen
dc.subjectchemotherapyen
dc.subjectifosfamideen
dc.subjectmetastasisen
dc.subjectosteosarcomaen
dc.subjectPEDIATRIC-ONCOLOGY-GROUPen
dc.subjectHIGH-DOSE IFOSFAMIDEen
dc.subjectAPPENDICULAR OSTEOSARCOMAen
dc.subjectOSTEO-SARCOMAen
dc.subjectDOGSen
dc.subjectCISPLATINen
dc.subjectAMPUTATIONen
dc.subjectCHEMOTHERAPYen
dc.subjectDOXORUBICINen
dc.subjectNEPHROTOXICITYen
dc.titleEvaluation of ifosfamide salvage therapy formetastatic canine osteosarcomaen
dc.title.serialVeterinary and Comparative Oncologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Small Animal Clinical Sciencesen

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