Dietary epicatechin improves survival and delays skeletal muscle degeneration in aged mice

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dc.contributor.authorSi, Hongweien
dc.contributor.authorWang, Xiaoyongen
dc.contributor.authorZhang, Longyunen
dc.contributor.authorParnell, Laurence D.en
dc.contributor.authorAdmed, Bulbulen
dc.contributor.authorLeRoith, Tanyaen
dc.contributor.authorAnsah, Twum-Ampofoen
dc.contributor.authorZhang, Lijuanen
dc.contributor.authorLi, Jianweien
dc.contributor.authorOrdovas, Jose M.en
dc.contributor.authorSi, Hongzongen
dc.contributor.authorLiu, Dongminen
dc.contributor.authorLai, Chao-Qiangen
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2019-08-30T17:00:08Zen
dc.date.available2019-08-30T17:00:08Zen
dc.date.issued2019-01en
dc.description.abstractWe recently reported that epicatechin, a bioactive compound that occurs naturally in various common foods, promoted general health and survival of obese diabetic mice. It remains to be determined whether epicatechin extends health span and delays the process of aging. In the present study, epicatechin or its analogue epigallocatechin gallate (EGCG) (0.25% w/v in drinking water) was administered to 20-mo-old male C57BL mice fed a standard chow. The goal was to determine the antiaging effect. The results showed that supplementation with epicatechin for 37 wk strikingly increased the survival rate from 39 to 69%, whereas EGCG had no significant effect. Consistently, epicatechin improved physical activity, delayed degeneration of skeletal muscle (quadriceps), and shifted the profiles of the serum metabolites and skeletal muscle general mRNA expressions in aging mice toward the profiles observed in young mice. In particular, we found that dietary epicatechin significantly reversed age-altered mRNA and protein expressions of extracellular matrix and peroxisome proliferator-activated receptor pathways in skeletal muscle, and reversed the age-induced declines of the nicotinate and nicotinamide pathway both in serum and skeletal muscle. The present study provides evidence that epicatechin supplementation can exert an antiaging effect, including an increase in survival, an attenuation of the aging-related deterioration of skeletal muscles, and a protection against the aging-related decline in nicotinate and nicotinamide metabolism.Si, H., Wang, X., Zhang, L., Parnell, L. D., Admed, B., LeRoith, T., Ansah, T.-A., Zhang, L., Li, J., Ordovas, J. M., Si, H., Liu, D., Lai, C.-Q. Dietary epicatechin improves survival and delays skeletal muscle degeneration in aged mice.en
dc.description.notesD. L. (doliu@ vt. edu) contributed equally to this work with H.S. and C.-Q.L. and can be contacted with questions and concerns. This work was supported by grants from the U.S. Department of Agriculture (USDA) Evans-Allen Program (TENX-1506-FS and TENX-1103-FS to H.S.) and a USDA 1890 Faculty Fellowship (58-8050-6-006 to H.S. and C.-Q.L.). Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the view of the USDA. Mention of trade names or commercial products in this publication is solely for the purpose of providing specific information and does not imply recommendation or endorsement by the USDA. The USDA is an equal opportunity provider and employer. The authors declare no conflicts of interest.en
dc.description.sponsorshipU.S. Department of Agriculture (USDA) Evans-Allen Program [TENX-1506-FS, TENX-1103-FS]; USDA 1890 Faculty Fellowship [58-8050-6-006]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1096/fj.201800554RRen
dc.identifier.eissn1530-6860en
dc.identifier.issn0892-6638en
dc.identifier.issue1en
dc.identifier.pmid30096038en
dc.identifier.urihttp://hdl.handle.net/10919/93324en
dc.identifier.volume33en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectantiagingen
dc.subjectextracellular matrix pathwayen
dc.subjectnicotinamide pathwayen
dc.subjectPPAR pathwayen
dc.subjectlifespanen
dc.titleDietary epicatechin improves survival and delays skeletal muscle degeneration in aged miceen
dc.title.serialFaseb Journalen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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