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Effect of Localized Mechanical Indentation on Skin Water Content Evaluated Using OCT

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dc.contributor.authorGurjarpadhye, Abhijit A.en
dc.contributor.authorVogt, William C.en
dc.contributor.authorLiu, Yajingen
dc.contributor.authorRylander, Christopher G.en
dc.contributor.departmentMechanical Engineeringen
dc.contributor.departmentSchool of Biomedical Engineering and Sciencesen
dc.date.accessioned2017-09-18T09:52:43Zen
dc.date.available2017-09-18T09:52:43Zen
dc.date.issued2011-08-04en
dc.date.updated2017-09-18T09:52:43Zen
dc.description.abstractThe highly disordered refractive index distribution in skin causes multiple scattering of incident light and limits optical imaging and therapeutic depth. We hypothesize that localized mechanical compression reduces scattering by expulsing unbound water from the dermal collagen matrix, increasing protein concentration and decreasing the number of index mismatch interfaces between tissue constituents. A swept-source optical coherence tomography (OCT) system was used to assess changes in thickness and group refractive index in ex vivo porcine skin, as well as changes in signal intensity profile when imaging in vivo human skin. Compression of ex vivo porcine skin resulted in an effective strain of −58.5%, an increase in refractive index from 1.39 to 1.50, and a decrease in water volume fraction from 0.66 to 0.20. In vivo OCT signal intensity increased by 1.5 dB at a depth of 1 mm, possibly due to transport of water away from the compressed regions. These finding suggest that local compression could be used to enhance light-based diagnostic and therapeutic techniques.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAbhijit A. Gurjarpadhye, William C. Vogt, Yajing Liu, and Christopher G. Rylander, “Effect of Localized Mechanical Indentation on Skin Water Content Evaluated Using OCT,” International Journal of Biomedical Imaging, vol. 2011, Article ID 817250, 8 pages, 2011. doi:10.1155/2011/817250en
dc.identifier.doihttps://doi.org/10.1155/2011/817250en
dc.identifier.urihttp://hdl.handle.net/10919/79023en
dc.language.isoenen
dc.publisherHindawien
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderCopyright © 2011 Abhijit A. Gurjarpadhye et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleEffect of Localized Mechanical Indentation on Skin Water Content Evaluated Using OCTen
dc.title.serialInternational Journal of Biomedical Imagingen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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