Exploring the activity of a polyazine bridged Ru(ii)-Pt(ii) supramolecule in F98 rat malignant glioma cells

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dc.contributor.authorZhu, Jieen
dc.contributor.authorRodriguez-Corrales, José Á.en
dc.contributor.authorPrussin, Reeceen
dc.contributor.authorZhao, Zongminen
dc.contributor.authorDominijanni, Anthonyen
dc.contributor.authorHopkins, Samantha L.en
dc.contributor.authorWinkel, Brenda S. J.en
dc.contributor.authorRobertson, John L.en
dc.contributor.authorBrewer, Karen J.en
dc.contributor.departmentChemistryen
dc.contributor.departmentBiomedical Engineering and Sciencesen
dc.contributor.departmentBiological Systems Engineeringen
dc.contributor.departmentBiological Sciencesen
dc.date.accessioned2017-05-01T06:42:16Zen
dc.date.available2017-05-01T06:42:16Zen
dc.date.issued2016-11-07en
dc.description.abstractThe mixed-metal supramolecular complex, [(Ph2phen)2Ru(dpp)PtCl2]2+, displays significant DNA modification, cell growth inhibition, and toxicity towards F98 malignant glioma cells following visible light irradiation. The design of this complex affords superior cellular uptake and antiproliferative activity compared to the classic chemotherapeutic agent, cisplatin.en
dc.format.extent145-148en
dc.format.mimetypeapplication/pdfen
dc.identifierc6cc07978d.pdfen
dc.identifierc6cc07978d1.pdfen
dc.identifier.doihttps://doi.org/10.1039/c6cc07978den
dc.identifier.eissn1364-548Xen
dc.identifier.issn1359-7345en
dc.identifier.issue1en
dc.identifier.urihttp://hdl.handle.net/10919/77547en
dc.identifier.volume53en
dc.language.isoen_USen
dc.publisherRoyal Society of Chemistryen
dc.relation.ispartofRoyal Society of Chemistry Gold Open Access - 2016en
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unporteden
dc.rights.holderZhu, Jieen
dc.rights.holderRodriguez-Corrales, José Á.en
dc.rights.holderPrussin, Reeceen
dc.rights.holderZhao, Zongminen
dc.rights.holderDominijanni, Anthonyen
dc.rights.holderHopkins, Samantha L.en
dc.rights.holderWinkel, Brenda S.en
dc.rights.holderRobertson, John L.en
dc.rights.holderBrewer, Karen J.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/en
dc.titleExploring the activity of a polyazine bridged Ru(ii)-Pt(ii) supramolecule in F98 rat malignant glioma cellsen
dc.title.serialChemical Communicationsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeDataseten

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