MicroRNAs Implicated in the Immunopathogenesis of Lupus Nephritis

Chafin, Cristen B.; Reilly, Christopher M.

MicroRNAs Implicated in the Immunopathogenesis of Lupus Nephritis

dc.contributor.author	Chafin, Cristen B.	en
dc.contributor.author	Reilly, Christopher M.	en
dc.date.accessioned	2017-09-18T09:45:12Z	en
dc.date.available	2017-09-18T09:45:12Z	en
dc.date.issued	2013-07-07	en
dc.date.updated	2017-09-18T09:45:12Z	en
dc.description.abstract	Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the deposition of immune complexes due to widespread loss of immune tolerance to nuclear self-antigens. Deposition in the renal glomeruli results in the development of lupus nephritis (LN), the leading cause of morbidity and mortality in SLE. In addition to the well-recognized genetic susceptibility to SLE, disease pathogenesis is influenced by epigenetic regulators such as microRNAs (miRNAs). miRNAs are small, noncoding RNAs that bind to the 3′ untranslated region of target mRNAs resulting in posttranscriptional gene modulation. miRNAs play an important and dynamic role in the activation of innate immune cells and are critical in regulating the adaptive immune response. Immune stimulation and the resulting cytokine milieu alter miRNA expression while miRNAs themselves modify cellular responses to stimulation. Here we examine dysregulated miRNAs implicated in LN pathogenesis from human SLE patients and murine lupus models. The effects of LN-associated miRNAs in the kidney, peripheral blood mononuclear cells, macrophages, mesangial cells, dendritic cells, and splenocytes are discussed. As the role of miRNAs in immunopathogenesis becomes delineated, it is likely that specific miRNAs may serve as targets for therapeutic intervention in the treatment of LN and other pathologies.	en
dc.description.version	Published version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Cristen B. Chafin and Christopher M. Reilly, “MicroRNAs Implicated in the Immunopathogenesis of Lupus Nephritis,” Clinical and Developmental Immunology, vol. 2013, Article ID 430239, 13 pages, 2013. doi:10.1155/2013/430239	en
dc.identifier.doi	https://doi.org/10.1155/2013/430239	en
dc.identifier.uri	http://hdl.handle.net/10919/78979	en
dc.language.iso	en	en
dc.publisher	Hindawi	en
dc.rights	Creative Commons Attribution 4.0 International	en
dc.rights.holder	Copyright © 2013 Cristen B. Chafin and Christopher M. Reilly. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.	en
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	en
dc.title	MicroRNAs Implicated in the Immunopathogenesis of Lupus Nephritis	en
dc.title.serial	Clinical and Developmental Immunology	en
dc.type	Article - Refereed	en
dc.type.dcmitype	Text	en