Hepatitis E virus infection in high-risk populations in Osun State, Nigeria

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dc.contributor.authorOsundare, Folakemi Abiodunen
dc.contributor.authorKlink, Patrycjaen
dc.contributor.authorAkanbi, Olusola Aanuoluwapoen
dc.contributor.authorWang, Boen
dc.contributor.authorHarms, Dominiken
dc.contributor.authorOjurongbe, Olusolaen
dc.contributor.authorAjayi, Moses Adedapoen
dc.contributor.authorBabaranti, Emmanuel Oluwagbengaen
dc.contributor.authorBock, C.-Thomasen
dc.contributor.authorOpaleye, Oladele Oluyinkaen
dc.coverage.countryNigeriaen
dc.date.accessioned2021-12-09T19:43:33Zen
dc.date.available2021-12-09T19:43:33Zen
dc.date.issued2021-12en
dc.description.abstractHepatitis E virus (HEV) infection is an emerging infection that is of major public health concern, especially in some vulnerable groups like immunosuppressed individuals, pregnant women and HBV-coinfected individuals. HEV is transmitted faecal/oral or zoonotically depending on the HEV-genotype. This study aimed at investigating HEV infections among different at-risk populations in Osun State, Southwestern Nigeria. A total of 720 serum samples were collected from animal handlers, pregnant women, people living with HIV/AIDS, and Hepatitis B virus (HBV) infected individuals. Commercially available Enzyme-Linked Immunosorbent Assays (ELISA) were used for the detection of anti-HEV total and IgM antibodies. Polymerase chain reaction (PCR) was carried out in the HEV seropositive samples and all the samples from individuals infected with HBV. Descriptive analysis and chi-square test of association were performed. The anti-HEV total antibody seroprevalence in HIV-positive individuals, animal handlers and pregnant women was 11.4% (n = 47/411), 7.9% (n = 7/89), and 6.3% (n = 10/160), respectively. Markers of acute HEV infection (anti-HEV IgM) were detected in 2.2% of HIV-positive individuals (n = 9/411) and 1.8% of animal handlers (n = 2/89), respectively, and in 0.6% of pregnant women (n =1/160). However, all samples were HEV RNA negative. This study analysed the presence of markers of HEV infection among different at-risk populations without clinical symptoms of HEV infection. Our results showed that HEV is an underestimated threat to public health in Nigeria and underlines the need of an HEV surveillance system to understand the distribution and transmission of HEV infection in animals and/to humans.en
dc.description.notesThis study was supported by a grant from the German Federal Ministry of Health regarding a decision of the German Bundestag by the Federal Government (NiCaDe-Project grant No: ZMVI-2519GHP711, and CHED-Project grant No: ZMVI1-2518FSB705). F.A.O. and O.O.O. are funded by a sub-project of the Global Health Protection Programme supported by the German Federal Ministry of Health based on a decision by the German Bundestag, the Partnership in Postgraduate Education (PPE), Robert Koch Institute, Berlin, Germany. O.A.A. is supported by funding of DAAD, Germany (German Academic Exchange Service; grant ID 57299293). B.W. is supported by the China Scholarship Council (CSC), Beijing, China. D.H. is supported by the Claussen-Simon-Stiftung (Claussen-Simon Foundation; CSF) "Dissertation Plus" program, Germany, and the Fazit-Stiftung, Germany, "Promotions Stipendium". The funders BMG, CSC, DAAD, Fazit, CSF, and GHPP/PPE had no role in study design, data collection and interpretation, or the decision to submit the work for publication. The content is the responsibility only of the authors and does not represent the views of the funders.en
dc.description.sponsorshipGerman Federal Ministry of Health regarding a decision of the German Bundestag by the Federal Government [ZMVI-2519GHP711, ZMVI1-2518FSB705]; German Federal Ministry of Health; Postgraduate Education (PPE), Robert Koch Institute, Berlin, Germany; DAAD, Germany (German Academic Exchange Service)Deutscher Akademischer Austausch Dienst (DAAD) [57299293]; China Scholarship Council (CSC), Beijing, ChinaChina Scholarship Council; Claussen-Simon-Stiftung (Claussen-Simon Foundation; CSF) "Dissertation Plus" program, Germany; Fazit-Stiftung, Germany, "Promotions Stipendium"en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.onehlt.2021.100256en
dc.identifier.eissn2352-7714en
dc.identifier.other100256en
dc.identifier.pmid34007873en
dc.identifier.urihttp://hdl.handle.net/10919/106895en
dc.identifier.volume13en
dc.language.isoenen
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectHepatitis E virusen
dc.subjectRisk populationen
dc.subjectHEV antibodiesen
dc.subjectELISAen
dc.subjectRT-PCRen
dc.subjectNigeriaen
dc.titleHepatitis E virus infection in high-risk populations in Osun State, Nigeriaen
dc.title.serialOne Healthen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
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