Not All Adversity is Created Equal: Differential Associations of Adversity Profiles with Adolescent Cognitive Control and Psychopathology

Adverse experiences have long-term consequences for biological, behavioral, and psychosocial adjustment. Adolescents may be particularly susceptible to these effects due to heightened sensitivity to environmental influences, the protracted development of the prefrontal cortex, and risk for psychopathology. We used a person-centered approach to characterize distinct profiles of adversity in early adolescence, and examined associations with later cognitive control and psychopathology. One hundred and sixty-seven adolescents (53% male) and their primary caregivers participated in a longitudinal study, with approximately one year in between each assessment. At Time 1 (Mage = 14.07 years), we collected reports on seven indicators of adversity: socioeconomic disadvantage, abuse, neglect, household chaos, parent substance use, parent depression, and negative life events. At Times 2, 3, and 4, adolescents' behavioral performance and blood-oxygenation-level-dependent response during a cognitive control task were measured. Two years later, at Time 5, adolescents and their caregiver reported on adolescent internalizing and externalizing symptomatology. Using latent profile analysis, we identified three distinct adversity subgroups: a low risk group, a low socioeconomic status (SES)/high parent substance use (SU) group, and a high risk group. Adolescents in the low SES/high parent SU group had the lowest levels of behavioral cognitive control. Furthermore, the low SES/high parent SU group and the high risk group both had significantly higher levels of psychopathology relative to the low risk group. There were no significant group differences with respect to neural cognitive control, and neither neural nor behavioral cognitive control predicted psychopathology. A cumulative risk approach using a mean score of adversity produced a similar general pattern of results, but obscured the unobserved heterogeneity in adverse experiences. These results highlight the utility of a person-centered approach to the characterization of adversity in adolescence and illustrate distinct developmental consequences for cognitive functioning and psychopathology. We expand upon prior empirical work by demonstrating that the co-occurrence of low SES and parent substance use may place adolescents at increased risk for deficits in behavioral cognitive control, which may be an important target for intervention and prevention efforts.