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Starting a Fire Without Flame: The Induction of Cell Death and Inflammation in Electroporation-Based Tumor Ablation Strategies

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dc.contributor.authorBrock, Rebecca M.en
dc.contributor.authorBeitel-White, Natalieen
dc.contributor.authorDavalos, Rafael V.en
dc.contributor.authorAllen, Irving C.en
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.contributor.departmentElectrical and Computer Engineeringen
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.date.accessioned2020-11-04T16:21:36Zen
dc.date.available2020-11-04T16:21:36Zen
dc.date.issued2020-07-28en
dc.description.abstractNew therapeutic strategies and paradigms are direly needed for the treatment of cancer. While the surgical removal of tumors is favored in most cancer treatment plans, resection options are often limited based on tumor localization. Over the last two decades, multiple tumor ablation strategies have emerged as promising stand-alone or combination therapeutic options for patients. These strategies are often employed to treat tumors in areas where surgical resection is not possible or where chemotherapeutics have proven ineffective. The type of cell death induced by the ablation modality is a critical aspect of therapeutic success that can impact the efficacy of the treatment and systemic anti-tumor immune system responses. Electroporation-based ablation technologies include electrochemotherapy, irreversible electroporation, and other modalities that rely on pulsed electric fields to create pores in cell membranes. These pores can either be reversible or irreversible depending on the electric field parameters and can induce cell death either alone or in combination with a therapeutic agent. However, there have been many controversial findings among these technologies as to the cell death type initiated, from apoptosis to pyroptosis. As cell death mechanisms can impact treatment side effects and efficacy, we review the main types of cell death induced by electroporation-based treatments and summarize the impact of these mechanisms on treatment response. We also discuss potential reasons behind the variability of findings such as the similarities between cell death pathways, differences between cell-types, and the variation in electric field strength across the treatment area.en
dc.description.notesThis work was supported by the Virginia-Maryland College of Veterinary Medicine (IA), the Virginia Tech Institute for Critical Technology and Applied Science Center for Engineered Health (IA and RD), the Virginia Biosciences Health Research Corporation Catalyst (RD), and the National Institutes of Health R01CA213423 (RD), P01CA207206 (RD), and R21EB028429 (IA). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or any other funding agency.en
dc.description.sponsorshipVirginia-Maryland College of Veterinary Medicine; Virginia Tech Institute for Critical Technology and Applied Science Center for Engineered Health; Virginia Biosciences Health Research Corporation Catalyst; National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01CA213423, P01CA207206, R21EB028429]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fonc.2020.01235en
dc.identifier.issn2234-943Xen
dc.identifier.other1235en
dc.identifier.pmid32850371en
dc.identifier.urihttp://hdl.handle.net/10919/100788en
dc.identifier.volume10en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectcanceren
dc.subjectApoptosisen
dc.subjectnecrosisen
dc.subjectpyroptosisen
dc.subjectcalciumen
dc.subjectelectroporationen
dc.subjectablationen
dc.titleStarting a Fire Without Flame: The Induction of Cell Death and Inflammation in Electroporation-Based Tumor Ablation Strategiesen
dc.title.serialFrontiers In Oncologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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