Probing Plant Metabolism: The Machineries of [Fe-S] Cluster Assembly and Flavonoid Biosynthesis

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dc.contributor.authorRamirez, Melissa V.en
dc.contributor.committeechairWinkel, Brenda S. J.en
dc.contributor.committeememberMcDowell, John M.en
dc.contributor.committeememberDean, Dennis R.en
dc.contributor.committeememberTholl, Dorotheaen
dc.contributor.committeememberSible, Jill C.en
dc.contributor.departmentBiologyen
dc.date.accessioned2017-04-06T15:43:21Zen
dc.date.adate2008-09-12en
dc.date.available2017-04-06T15:43:21Zen
dc.date.issued2008-08-06en
dc.date.rdate2016-10-17en
dc.date.sdate2008-08-20en
dc.description.abstractThe organization of metabolism is an essential feature of cellular biochemistry. Metabolism does not occur as a linear assembly of freely diffusing enzymes, but as a complex web in which multiple interactions are possible. Because of the crowded environment of the cell, there must be structured and ordered mechanisms that control metabolic pathways. The following work will examine two metabolic pathways, one that is ubiquitous among living organisms and another that is entirely unique to plants, and examine the organization of each in an attempt to further define mechanisms that are fundamental features of metabolic control. One study offers some of the first characterizations of genes involved in [Fe-S] cluster assembly in Arabidopsis. The other explores the mechanisms that control localization of an enzyme that is part of the well-characterized flavonoid biosynthetic pathway. These two distinct pathways serve as unique models for genetic and biochemical studies that contribute to our overall understanding of plant metabolism.en
dc.description.degreePh. D.en
dc.identifier.otheretd-08202008-083814en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-08202008-083814/en
dc.identifier.urihttp://hdl.handle.net/10919/77167en
dc.language.isoen_USen
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectintracellular localizationen
dc.subjectchalcone synthaseen
dc.subject[Fe-S] cluster assemblyen
dc.subjectflavonoid biosynthesisen
dc.subjectconfocal microscopyen
dc.titleProbing Plant Metabolism: The Machineries of [Fe-S] Cluster Assembly and Flavonoid Biosynthesisen
dc.typeDissertationen
dc.type.dcmitypeTexten
thesis.degree.disciplineBiologyen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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