Dietary Supplementation of Chinese Ginseng Prevents Obesity and Metabolic Syndrome in High-Fat Diet-Fed Mice

Simple item page
dc.contributor.authorLi, Xiaoxiaoen
dc.contributor.authorLuo, Jingen
dc.contributor.authorBabu, Pon Velayutham Anandhen
dc.contributor.authorZhang, Weien
dc.contributor.authorGilbert, Elizabeth R.en
dc.contributor.authorCline, Mark A.en
dc.contributor.authorMcMillan, Ryan P.en
dc.contributor.authorHulver, Matthew W.en
dc.contributor.authorAlkhalidy, Hanaen
dc.contributor.authorZhen, Weien
dc.contributor.authorZhang, Haiyanen
dc.contributor.authorLiu, Dongminen
dc.contributor.departmentAnimal and Poultry Sciencesen
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessed2016-02-09en
dc.date.accessioned2016-02-28T22:29:47Zen
dc.date.available2016-02-28T22:29:47Zen
dc.date.issued2014-12-01en
dc.description.abstractObesity and diabetes are growing health problems worldwide. In this study, dietary provision of Chinese ginseng (0.5 g/kg diet) prevented body weight gain in high-fat (HF) diet-fed mice. Dietary ginseng supplementation reduced body fat mass gain, improved glucose tolerance and whole body insulin sensitivity, and prevented hypertension in HF diet-induced obese mice. Ginseng consumption led to reduced concentrations of plasma insulin and leptin, but had no effect on plasma adiponectin levels in HF diet-fed mice. Body temperature was higher in mice fed the ginseng-supplemented diet but energy expenditure, respiration rate, and locomotive activity were not significantly altered. Dietary intake of ginseng increased fatty acid oxidation in the liver but not in skeletal muscle. Expression of several transcription factors associated with adipogenesis (C/EBP alpha and PPAR gamma) were decreased in the adipose tissue of HF diet-fed mice, effects that were mitigated in mice that consumed the HF diet supplemented with ginseng. Abundance of fatty acid synthase (FASN) mRNA was greater in the adipose tissue of mice that consumed the ginseng-supplemented HF diet as compared with control or un-supplemented HF diet-fed mice. Ginseng treatment had no effect on the expression of genes involved in the regulation of food intake in the hypothalamus. These data suggest that Chinese ginseng can potently prevent the development of obesity and insulin resistance in HF diet-fed mice.en
dc.description.sponsorshipAmerican Diabetes Associationen
dc.description.sponsorship7-11-BS-84en
dc.description.sponsorshipDiabetes Research and Action Education Foundationen
dc.description.sponsorshipNational Institutes of Health. National Center for Complementary and Alternative Medicineen
dc.description.sponsorship1R01AT007077en
dc.format.extent11 p.en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationLi, X., Luo, J., Anandh Babu, P. V., Zhang, W., Gilbert, E., Cline, M., McMillan, R., Hulver, M., Alkhalidy, H., Zhen, W., Zhang, H., & Liu, D. (2014). Dietary Supplementation of Chinese Ginseng Prevents Obesity and Metabolic Syndrome in High-Fat Diet-Fed Mice. Journal of Medicinal Food, 17(12), 1287-1297. doi:10.1089/jmf.2014.001en
dc.identifier.doihttps://doi.org/10.1089/jmf.2014.0016en
dc.identifier.issn1096-620Xen
dc.identifier.issue12en
dc.identifier.otherjmf20140016.pdfen
dc.identifier.urihttp://hdl.handle.net/10919/64872en
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/25076190en
dc.identifier.volume17en
dc.language.isoenen
dc.publisherMary Ann Lieberten
dc.rightsIn Copyrighten
dc.rights.holderMary Ann Liebert, Inc.en
dc.rights.holderKorean Society of Food Science and Nutritionen
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectGinsengen
dc.subjectMiceen
dc.subjectObesityen
dc.subjectFaten
dc.subjectInsulin resistanceen
dc.titleDietary Supplementation of Chinese Ginseng Prevents Obesity and Metabolic Syndrome in High-Fat Diet-Fed Miceen
dc.title.serialJournal of Medicinal Fooden
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
jmf20140016.pdf
Size:
534.99 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Scholarly Works, Human Nutrition, Foods, and Exercise
Destination Area: Adaptive Brain and Behavior (ABB)
Destination Area: Data and Decisions (D&D)
Scholarly Works, School of Animal Sciences