The Modulating Effect of Dietary Beta-Glucan Supplementation on Expression of Immune Response Genes of Broilers during a Coccidiosis Challenge

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dc.contributor.authorOmara, Islam I.en
dc.contributor.authorPender, Chasity M.en
dc.contributor.authorWhite, Mallory B.en
dc.contributor.authorDalloul, Rami A.en
dc.contributor.departmentAnimal and Poultry Sciencesen
dc.date.accessioned2021-06-11T15:14:53Zen
dc.date.available2021-06-11T15:14:53Zen
dc.date.issued2021-01en
dc.description.abstractSimple Summary Avian coccidiosis is the leading parasitic disease in the poultry industry and means to control its damages continue to be explored. This study evaluated the feeding effects of a yeast-derived beta-glucan on expression of immune response genes in the spleen, thymus, and bursa of commercial broiler chickens during an Eimeria challenge. The study consisted of two dietary treatments (0% or 0.1% beta-glucan) each with or without a coccidiosis challenge. There were significant effects from dietary beta-glucan, Eimeria challenge, and their interaction for several gene targets in the spleen, thymus, and bursa on days 10 and 14 of age. Based on the current results, supplementation of dietary beta-glucan in Eimeria-challenged birds enhanced and modulated the expression of immune response genes during coccidiosis. This study investigated the effects of a yeast-derived beta-glucan (Auxoferm YGT) supplementation on mRNA expression of immune response genes in the spleen, thymus, and bursa of broiler chickens during a mixed Eimeria infection. Day (d)-old chicks (n = 1440) were fed diets containing 0% or 0.1% YGT. On d 8 post-hatch, half the replicate pens (n = 8) were challenged with a mixed inoculum of E. acervulina, E. maxima, and E. tenella. On d 10 and d 14 post-hatch, the spleen, thymus, and bursa were collected to evaluate mRNA abundance by quantitative real-time PCR. Data were analyzed using PROC GLIMMIX model (2-way interaction) and differences were established by LS-MEANS with significance reported at p <= 0.05. In spleen tissues at d 10, expression of interleukin (IL)-10 and inducible nitric oxide synthase (iNOS) were elevated in both 0.1% YGT-fed challenged and non-challenged birds. In thymus tissues at d 14, expression of IL-10, IL-17F, interferon (IFN)-gamma, iNOS, and macrophage migration inhibitory factor (MIF) were elevated in challenged birds fed 0.1% YGT. In bursal tissues at d 10 and d 14, expression of IL-10, IFN-gamma, iNOS (d 10 only), and MIF were elevated in 0.1% YGT-fed challenged and non-challenged birds. Dietary beta-glucan supplementation to chicken diets modulated their immune response to the Eimeria challenge.en
dc.description.notesThis work was supported in part by the USDA National Institute of Food and Agriculture (NIFA) Hatch funds to the Virginia Agricultural Experiment Station.en
dc.description.sponsorshipUSDA National Institute of Food and Agriculture (NIFA) Hatch fundsen
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3390/ani11010159en
dc.identifier.issn2076-2615en
dc.identifier.issue1en
dc.identifier.other159en
dc.identifier.pmid33445562en
dc.identifier.urihttp://hdl.handle.net/10919/103785en
dc.identifier.volume11en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectβ-glucanen
dc.subjectbroileren
dc.subjectcytokineen
dc.subjectcoccidiosisen
dc.subjectimmunityen
dc.titleThe Modulating Effect of Dietary Beta-Glucan Supplementation on Expression of Immune Response Genes of Broilers during a Coccidiosis Challengeen
dc.title.serialAnimalsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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