Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPAR

Carter, Ashlee B.; Misyak, Sarah A.; Hontecillas, Raquel; Bassaganya-Riera, Josep

Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPAR

dc.contributor.author	Carter, Ashlee B.	en
dc.contributor.author	Misyak, Sarah A.	en
dc.contributor.author	Hontecillas, Raquel	en
dc.contributor.author	Bassaganya-Riera, Josep	en
dc.date.accessioned	2017-09-18T10:00:39Z	en
dc.date.available	2017-09-18T10:00:39Z	en
dc.date.issued	2009-04-22	en
dc.date.updated	2017-09-18T10:00:39Z	en
dc.description.abstract	Mounting evidence suggests that the risk of developing colorectal cancer (CRC) is dramatically increased for patients with chronic inflammatory diseases. For instance, patients with Crohn's Disease (CD) or Ulcerative Colitis (UC) have a 12–20% increased risk for developing CRC. Preventive strategies utilizing nontoxic natural compounds that modulate immune responses could be successful in the suppression of inflammation-driven colorectal cancer in high-risk groups. The increase of peroxisome proliferator-activated receptor- (PPAR-) expression and its transcriptional activity has been identified as a target for anti-inflammatory efforts, and the suppression of inflammation-driven colon cancer. PPAR down-modulates inflammation and elicits antiproliferative and proapoptotic actions in epithelial cells. All of which may decrease the risk for inflammation-induced CRC. This review will focus on the use of orally active, naturally occurring chemopreventive approaches against inflammation-induced CRC that target PPAR and therefore down-modulate inflammation.	en
dc.description.version	Published version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Ashlee B. Carter, Sarah A. Misyak, Raquel Hontecillas, and Josep Bassaganya-Riera, “Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPAR,” PPAR Research, vol. 2009, Article ID 498352, 9 pages, 2009. doi:10.1155/2009/498352	en
dc.identifier.doi	https://doi.org/10.1155/2009/498352	en
dc.identifier.uri	http://hdl.handle.net/10919/79053	en
dc.language.iso	en	en
dc.publisher	Hindawi	en
dc.rights	Creative Commons Attribution 4.0 International	en
dc.rights.holder	Copyright © 2009 Ashlee B. Carter et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.	en
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	en
dc.title	Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPAR	en
dc.title.serial	PPAR Research	en
dc.type	Article - Refereed	en
dc.type.dcmitype	Text	en