Baculovirus-directed expression of the phosphorylase kinase catalytic subunit: pseudosubstrate and calmodulin regulation

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dc.contributor.authorLanciotti, Robert Arthuren
dc.contributor.committeechairBender, Patrick K.en
dc.contributor.committeememberBevan, David R.en
dc.contributor.committeememberKennelly, Peter J.en
dc.contributor.committeememberLederman, Muriel L.en
dc.contributor.committeememberPotts, Malcolmen
dc.contributor.departmentBiochemistry and Anaerobic Microbiologyen
dc.date.accessioned2014-03-14T21:13:35Zen
dc.date.adate2008-06-06en
dc.date.available2014-03-14T21:13:35Zen
dc.date.issued1994-08-05en
dc.date.rdate2008-06-06en
dc.date.sdate2008-06-06en
dc.description.abstractPhosphorylase kinase (EC 2.7.1.38) is a key enzyme involved in the regulation of the glycogenolysis pathway. It catalyzes the Ca²⁺-dependent phosphorylation and activation of the enzyme glycogen phosphorylase to make the active form glycogen phosphorylase. Phosphorylase kinase is composed of 4 subunits with a stoichiometry of (αβγδ)₄. The γ subunit is the catalytic subunit. The regulatory domain (residues 277-387) of γ contains a sequence resembling the sites phosphorylated in known γ substrates with the exception that a valine₃₃₂ occurs at the analogous position of the phosphorylated serine or threonine residue.en
dc.description.degreePh. D.en
dc.format.extentxi, 125 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-06062008-163955en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-06062008-163955/en
dc.identifier.urihttp://hdl.handle.net/10919/38252en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V856_1994.L363.pdfen
dc.relation.isformatofOCLC# 31594033en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V856 1994.L363en
dc.subject.lcshBaculovirusesen
dc.subject.lcshCalmodulinen
dc.subject.lcshProtein kinasesen
dc.titleBaculovirus-directed expression of the phosphorylase kinase catalytic subunit: pseudosubstrate and calmodulin regulationen
dc.typeDissertationen
dc.type.dcmitypeTexten
thesis.degree.disciplineBiochemistry and Anaerobic Microbiologyen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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