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Modeling of nucleation-based stochastic processes in cellular systems

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dc.contributor.authorXu, Xiaohuaen
dc.contributor.committeechairKulkarni, Rahul V.en
dc.contributor.committeememberRobinson, Hans D.en
dc.contributor.committeememberPark, Kyungwhaen
dc.contributor.committeememberPleimling, Michel J.en
dc.contributor.departmentPhysicsen
dc.date.accessioned2014-03-14T20:15:40Zen
dc.date.adate2010-09-16en
dc.date.available2014-03-14T20:15:40Zen
dc.date.issued2010-08-11en
dc.date.rdate2010-09-16en
dc.date.sdate2010-08-24en
dc.description.abstractMolecular cell biology has been an intensively studied interdisciplinary field with the rapid development of experimental techniques and fast upgrade of computational hardware and numerical tools. Recent technological developments have led to single-cell experiments which allow us to probe the role of stochasticity in cellular processes. Stochastic modeling of the corresponding processes is thus an essential ingredient for the understanding and interpretation of cellular systems of interest. In this thesis, we explore several nucleation-based stochastic cellular processes, i.e. Min protein oscillation in Escherichia coli, pausing phenomena in DNA transcription, and single-molecule enzyme kinetics. We focus on the key experimental results and build up stochastic models accordingly to provide quantitative insights to the underlying physical mechanisms for the corresponding biological processes. We utilize specific mathematical methods and computational algorithms to gain a better understanding and make predictions for further experimental explorations in the relevant fields.en
dc.description.degreePh. D.en
dc.identifier.otheretd-08242010-161307en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-08242010-161307/en
dc.identifier.urihttp://hdl.handle.net/10919/28784en
dc.publisherVirginia Techen
dc.relation.haspartXiaohua_Xu_D_2010.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectstochastic modelingen
dc.subjectfirst passage timeen
dc.subjectnucleationen
dc.subjectsubcellular localizationen
dc.subjectbiophysicsen
dc.titleModeling of nucleation-based stochastic processes in cellular systemsen
dc.typeDissertationen
thesis.degree.disciplinePhysicsen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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