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The two-body problem: Proprioception and motor control across the metamorphic divide

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dc.contributor.authorAgrawal, Swetaen
dc.contributor.authorTuthill, John C.en
dc.date.accessioned2024-02-02T15:49:36Zen
dc.date.available2024-02-02T15:49:36Zen
dc.date.issued2022-05-02en
dc.description.abstractLike a rocket being propelled into space, evolution has engineered flies to launch into adulthood via multiple stages. Flies develop and deploy two distinct bodies, linked by the transformative process of metamorphosis. The fly larva is a soft hydraulic tube that can crawl to find food and avoid predators. The adult fly has a stiff exoskeleton with articulated limbs that enable long-distance navigation and rich social interactions. Because the larval and adult forms are so distinct in structure, they require distinct strategies for sensing and moving the body. The metamorphic divide thus presents an opportunity for comparative analysis of neural circuits. Here, we review recent progress toward understanding the neural mechanisms of proprioception and motor control in larval and adult Drosophila. We highlight commonalities that point toward general principles of sensorimotor control and differences that may reflect unique constraints imposed by biomechanics. Finally, we discuss emerging opportunities for comparative analysis of neural circuit architecture in the fly and other animal species.en
dc.description.versionAccepted versionen
dc.identifier102546 (Article number)en
dc.identifier.doihttps://doi.org/10.1016/j.conb.2022.102546en
dc.identifier.eissn1873-6882en
dc.identifier.issn0959-4388en
dc.identifier.orcidAgrawal, Sweta [0000-0003-0547-4099]en
dc.identifier.otherPMC9167723en
dc.identifier.otherS0959-4388(22)00040-X (PII)en
dc.identifier.pmid35512562en
dc.identifier.urihttps://hdl.handle.net/10919/117827en
dc.identifier.volume74en
dc.publisherElsevieren
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/35512562en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.meshAnimalsen
dc.subject.meshDrosophilaen
dc.subject.meshProprioceptionen
dc.subject.meshLarvaen
dc.titleThe two-body problem: Proprioception and motor control across the metamorphic divideen
dc.title.serialCurrent Opinion in Neurobiologyen
dc.typeArticle - Refereeden
dc.type.otherResearch Support, Non-U.S. Gov'ten
dc.type.otherresearch-articleen
dc.type.otherJournal Articleen
dc.type.otherResearch Support, N.I.H., Extramuralen
dcterms.dateAccepted2022-03-27en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen
pubs.organisational-group/Virginia Tech/Science/School of Neuroscienceen

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