Cognitive profiles in bipolar I disorder and associated risk factors: Using Wechsler adult intelligence scale-IV

dc.contributor.authorKo, Hayoungen
dc.contributor.authorPark, DongYeonen
dc.contributor.authorShin, Jaehyunen
dc.contributor.authorYu, Rinaen
dc.contributor.authorRyu, Vinen
dc.contributor.authorLee, Wonhyeen
dc.date.accessioned2023-05-02T19:08:46Zen
dc.date.available2023-05-02T19:08:46Zen
dc.date.issued2022-10en
dc.description.abstractBackground: Despite the growing evidence of cognitive impairments in bipolar disorder (BD), little work has evaluated cognitive performances utilizing the latest version of the Wechsler Intelligence Scale-IV (WAIS-IV), which is one of the most widely used neurocognitive assessments in clinical settings. Furthermore, clinical characteristics or demographic features that negatively affect the cognitive functioning of BD were not systematically compared or evaluated. Accordingly, the present study aimed to examine the cognitive profile of bipolar I disorder (BD-I) patients and associated risk factors. Methods: Participants included 45 patients, diagnosed with BD-I, current or most recent episode manic, and matching 46 healthy controls (HC). Cognitive performance was evaluated via WAIS-IV, and clinical characteristics of the BD-I group were examined via multiple self- and clinician-report questionnaires. Results: Multivariate analysis of covariance (MANCOVA) results indicated that the BD-I group demonstrated significantly poorer performance compared to the HC group in subtests and indexes that reflect working memory and processing speed abilities. Redundancy analysis revealed that overall symptom severity, manic symptom severity, and anxiety were significant predictors of cognitive performance in BD-I, while age of onset, past mood disorder history, depression severity, and impulsiveness showed comparatively smaller predictive values. Conclusion: The current study suggests cognitive deterioration in the cognitive proficiency area while generalized ability, including verbal comprehension and most of the perceptual reasoning skills, remain intact in BD-I. The identified risk factors of cognitive performance provide specific clinical recommendations for intervention and clinical decision-making.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fpsyg.2022.951043en
dc.identifier.other951043en
dc.identifier.pmid36275296en
dc.identifier.urihttp://hdl.handle.net/10919/114897en
dc.identifier.volume13en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectWechsler Intelligence Scale-IV (WAIS-IV)en
dc.subjectbipolar I disorderen
dc.subjectcognitive performanceen
dc.subjectrisk factorsen
dc.subjectredundancy analysisen
dc.titleCognitive profiles in bipolar I disorder and associated risk factors: Using Wechsler adult intelligence scale-IVen
dc.title.serialFrontiers in Psychologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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