Probable paraneoplastic leukocytosis in a dog with a gastrointestinal stromal tumor

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dc.contributor.authorGidcumb, Emily M.en
dc.contributor.authorBolton, Timothy A.en
dc.contributor.authorTrusiano, Brieen
dc.contributor.authorZimmerman, Kurt L.en
dc.contributor.authorOakes, Vanessa J.en
dc.date.accessioned2022-06-15T14:08:33Zen
dc.date.available2022-06-15T14:08:33Zen
dc.date.issued2022-05-09en
dc.description.abstractA 9-year-old female spayed Boston Terrier presented for diagnostic investigation of lethargy, poor appetite, weight loss, and a marked leukocytosis. Significant muscle wasting and a palpable abdominal mass were present on physical examination. Abdominal imaging revealed the mass to be of small intestinal origin; consequently, an intestinal resection and anastomosis were performed without complication. The histopathologic diagnosis was a gastrointestinal stromal tumor, verified by immunohistochemical positivity to CD117 (KIT). Two weeks after discharge, the leukocytosis had resolved. Though the exact molecular mediator of the severe leukocytosis was undetermined, resolution following tumor removal suggests a paraneoplastic cause. To the authors' knowledge, this is the first reported case of probable paraneoplastic leukocytosis secondary to a gastrointestinal stromal tumor in the dog. Gastrointestinal tract imaging should be performed when this uncommon hematologic abnormality is present.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/vcp.13143en
dc.identifier.eissn1939-165Xen
dc.identifier.issn0275-6382en
dc.identifier.pmid35534919en
dc.identifier.urihttp://hdl.handle.net/10919/110782en
dc.language.isoenen
dc.publisherWileyen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectCD117 (KIT)en
dc.subjectdogen
dc.subjectgastrointestinal tracten
dc.subjectimmunohistochemistryen
dc.subjectneutrophiliaen
dc.titleProbable paraneoplastic leukocytosis in a dog with a gastrointestinal stromal tumoren
dc.title.serialVeterinary Clinical Pathologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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