Solution Properties and Electrospinning of Phosphonium Gemini Surfactants

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dc.contributorVirginia Tech. Department of Chemistryen
dc.contributorMacromolecules and Interfaces Institute at Virginia Techen
dc.contributor.authorHemp, Sean T.en
dc.contributor.authorHudson, Amanda G.en
dc.contributor.authorAllen, Michael H. Jr.en
dc.contributor.authorPole, Sandeep S.en
dc.contributor.authorMoore, Robert Bowenen
dc.contributor.authorLong, Timothy E.en
dc.contributor.departmentChemistryen
dc.date.accessed2015-04-16en
dc.date.accessioned2015-04-20T18:49:34Zen
dc.date.available2015-04-20T18:49:34Zen
dc.date.issued2014-04-14en
dc.description.abstractBis(diphenylphosphino)alkanes quantitatively react with excess 1-bromododecane to prepare novel phosphonium gemini surfactants with spacer lengths ranging from 2 to 4 methylenes (12-2/3/4-12P). Dodecyltriphenylphosphonium bromide (DTPP), a monomeric surfactant analog, was readily water soluble, however, in sharp contrast, phosphonium gemini surfactants were poorly soluble in water due to two hydrophobic tails and relatively hydrophobic cationic head groups containing phenyl substituents. Isothermal titration calorimetry did not reveal a measurable critical micelle concentration for the 12-2-12P phosphonium gemini surfactant in water at 25C. Subsequent studies in 50/50 v/v water_methanol at 25C showed a CMC of 1.0 mM for 12-2-12P. All phosphonium gemini surfactants effectively complexed nucleic acids, but failed to deliver nucleic acids in vitro to HeLa cells. The solution behavior of phosphonium gemini surfactants was investigated in chloroform, which is an organic solvent where reverse micellar structures are favored. Solution rheology in chloroform explored the solution behavior of the phosphonium gemini surfactants compared to DTPP. The 12-2-12P and 12-3-12P gemini surfactants were successfully electrospun from chloroform to generate uniform fibers while 12-4-12P gemini surfactant and DTPP only electrosprayed to form droplets.en
dc.description.notesSupplementary information is included in a separate fileen
dc.description.sponsorshipUnited States. Army Research Office - grant number W911NF-07-1-0452, Ionic Liquids in Electro-Active Devices (ILEAD) MURIen
dc.description.sponsorshipU.S. Army Research Laboratoryen
dc.description.sponsorshipUnited States. Army Research Office. Army Materials Center of Excellence Program - Contract W911NF-06-2-0014en
dc.description.sponsorshipNational Science Foundation (U.S.) - Grant no. DMR-0923107en
dc.description.sponsorshipNational Science Foundation (U.S.) - CHE-0722638en
dc.description.sponsorshipUnited States. Army Research Office. (ARO) - Award no. W911NF-10-1-0307 (DURIP)en
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHemp, S. T., Hudson, A. G., Allen, M. H., Pole, S. S., Moore, R. B., & Long, T. E. (2014). Solution properties and electrospinning of phosphonium gemini surfactants. Soft Matter, 10(22), 3970-3977. doi: 10.1039/C4SM00271Gen
dc.identifier.doihttps://doi.org/10.1039/C4SM00271Gen
dc.identifier.issn1744-683Xen
dc.identifier.urihttp://hdl.handle.net/10919/51699en
dc.identifier.urlhttp://pubs.rsc.org/en/content/articlelanding/2014/sm/c4sm00271gen
dc.language.isoen_USen
dc.publisherThe Royal Society of Chemistryen
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unporteden
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/en
dc.subjectBis(diphenylphosphino)alkanesen
dc.subjectGemini surfactantsen
dc.subjectPhosphonium gemini surfactantsen
dc.subjectElectrospinningen
dc.subjectPolyplex formation and characterizationen
dc.titleSolution Properties and Electrospinning of Phosphonium Gemini Surfactantsen
dc.title.serialSoft Matteren
dc.typeArticle - Refereeden
dc.typeDataseten
dc.type.dcmitypeTexten
dc.type.dcmitypeDataseten
dc.type.dcmitypeImageen

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