The study of capillary electrophoresis: polyimides, nylon and non-aqueous analysis

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dc.contributor.authorSun, Xiaoweien
dc.contributor.committeechairMcNair, Harold M.en
dc.contributor.committeememberAnderson, Mark R.en
dc.contributor.committeememberGibson, Harry W.en
dc.contributor.committeememberGlanville, James O.en
dc.contributor.committeememberLong, Gary L.en
dc.contributor.departmentChemistryen
dc.date.accessioned2014-03-14T21:10:55Zen
dc.date.adate2006-05-11en
dc.date.available2014-03-14T21:10:55Zen
dc.date.issued1996en
dc.date.rdate2006-05-11en
dc.date.sdate2006-05-11en
dc.description.abstractNew applications of capillary zone electrophoresis (CZE) are explored. These include condensation polymer compositional analysis (1,2,3), drug in urine analysis (4) and nonaqueous CE (5) by using a mixture of N Methylformamide (NMF) and dimethylsulfoxide (DMSO). First, the application of CZE to polyimide compositional analysis is described. The electropherograms of decomposed products from polyimide are determined by the structure of monomers from which a polyimide is made. In most cases, it is difficult to know structures for all peaks that appear in the electropherogram. But different polyimides give different patterns on the electropherogram and the same monomer in different polyimides gives a similar pattern. This pattern of electropherogram can be considered as a "fingerprint" of the polyimide, just as a chromatogram obtained from pyrolysis GC analysis of a polymer. It is possible to deduce the major components of the polyimide from the pattern of the electropherogram of the decomposition products of the polyimide. Second, the application of CZE to nylon compositional analysis is studied. The hydrolysis of nylon in acidic condition gives its corresponding monomer. There is no further decomposition reaction of the monomer. This method is simple and easy. Analysis of trace amount amine impurities is possible, which is very difficult to do by other methods. Third, a method for ranitidine, an ulcer disease, in urine is developed. Solid phase extraction conditions and the CZE procedure conditions are optimized. Experimental results show that good recovery of the drug from a urine sample and relatively good reproducibility are obtained. Finally, non-aqueous CE using a mixture of NMF and DMSO as solvent is studied. The separation of a mixture of aromatic acids by this solvent is described.en
dc.description.degreePh. D.en
dc.format.extentix, 116 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-05112006-154816en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-05112006-154816/en
dc.identifier.urihttp://hdl.handle.net/10919/37766en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V856_1996.S86.pdfen
dc.relation.isformatofOCLC# 34843777en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V856 1996.S86en
dc.titleThe study of capillary electrophoresis: polyimides, nylon and non-aqueous analysisen
dc.typeDissertationen
dc.type.dcmitypeTexten
thesis.degree.disciplineChemistryen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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