Utility of the Non-Alcoholic Fatty Liver Disease Fibrosis Score in the Evaluation of Individuals with Medically-Complicated Obesity: A Retrospective Study

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dc.contributor.authorNath, Ananden
dc.contributor.authorShope, Timothy R.en
dc.contributor.authorPardo Lameda, Ivanesa L.en
dc.contributor.authorKoch, Timothy R.en
dc.date.accessioned2024-12-02T14:25:55Zen
dc.date.available2024-12-02T14:25:55Zen
dc.date.issued2024-10-02en
dc.description.abstractBackground: Individuals with high body mass index (BMI) are at risk for chronic liver disease. Liver biopsy is a gold standard for the diagnosis of liver disease, as well as for determining the NAFLD activity score and fibrosis stage. Blood alanine aminotransferase (ALT) can support the presence of steatohepatitis, while the non-alcoholic fatty liver disease (NAFLD) fibrosis score (using clinical features and blood testing) may predict fibrosis. Based on prior studies, it is not clear whether the NAFLD fibrosis score is predictive of the NAFLD activity score or fibrosis stage. Aims: The aim was to examine whether clinical features and blood testing can identify the risk of chronic liver disease in those individuals with high BMI. Objective: Individuals with high BMI who may benefit from bariatric surgery were examined for the prevalence of steatohepatitis and for potential relationships between the NAFLD fibrosis score and the NAFLD activity score and fibrosis stage. Methods: This was a retrospective study of 593 consecutive individuals evaluated for bariatric surgery who underwent blood testing. Seventy individuals with a mean BMI of 49.9 kg/m2 underwent liver biopsy at surgery. Results: Elevated ALT was present in 102 subjects (17.2%). The correlation coefficient (R: 0.025; p = 0.83) between the NAFLD fibrosis score and NAFLD activity score was not significant, but there was a weak correlation between the NAFLD fibrosis score and fibrosis stage (R = 0.262; p = 0.28). Two individuals (3%) had cirrhosis. Conclusion: Elevated ALT may support the presence of liver disease in individuals with high BMI. There is a weak correlation between the NAFLD fibrosis score and the fibrosis stage. Further work is required to determine whether specific blood and clinical findings can be useful in making clinical decisions with regards to bariatric surgery in those individuals with high BMI.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.2174/0126662906296409240826050717en
dc.identifier.issn2666-2906en
dc.identifier.orcidKoch, Timothy [0000-0002-8026-9653]en
dc.identifier.urihttps://hdl.handle.net/10919/123668en
dc.identifier.volume03en
dc.language.isoenen
dc.publisherBentham Science Publishersen
dc.rightsPublic Domain (U.S.)en
dc.rights.urihttp://creativecommons.org/publicdomain/mark/1.0/en
dc.subject Non-alcoholic fatty liver diseaseen
dc.subjectsteatohepatitisen
dc.subjectbiopsyen
dc.subjectalanine aminotransferaseen
dc.subjectbody mass indexen
dc.subjectbody sizeen
dc.titleUtility of the Non-Alcoholic Fatty Liver Disease Fibrosis Score in the Evaluation of Individuals with Medically-Complicated Obesity: A Retrospective Studyen
dc.title.serialThe International Journal of Gastroenterology and Hepatology Diseasesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-groupVirginia Techen
pubs.organisational-groupVirginia Tech/VT Carilion School of Medicineen
pubs.organisational-groupVirginia Tech/VT Carilion School of Medicine/Internal Medicineen
pubs.organisational-groupVirginia Tech/VT Carilion School of Medicine/Internal Medicine/General IMen

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