Antibiotic exposure is associated with decreased risk of psychiatric disorders
| dc.contributor.author | Kerman, Ilan A. | en |
| dc.contributor.author | Glover, Matthew E. | en |
| dc.contributor.author | Lin, Yezhe | en |
| dc.contributor.author | West, Jennifer L. | en |
| dc.contributor.author | Hanlon, Alexandra L. | en |
| dc.contributor.author | Kablinger, Anita S. | en |
| dc.contributor.author | Clinton, Sarah M. | en |
| dc.date.accessioned | 2024-03-15T14:57:20Z | en |
| dc.date.available | 2024-03-15T14:57:20Z | en |
| dc.date.issued | 2024-01-08 | en |
| dc.description.abstract | Objective: This study sought to investigate the relationship between antibiotic exposure and subsequent risk of psychiatric disorders. Methods: This retrospective cohort study used a national database of 69 million patients from 54 large healthcare organizations. We identified a cohort of 20,214 (42.5% male; 57.9 ± 15.1 years old [mean ± SD]) adults without prior neuropsychiatric diagnoses who received antibiotics during hospitalization. Matched controls included 41,555 (39.6% male; 57.3 ± 15.5 years old) hospitalized adults without antibiotic exposure. The two cohorts were balanced for potential confounders, including demographics and variables with potential to affect: the microbiome, mental health, medical comorbidity, and overall health status. Data were stratified by age and by sex, and outcome measures were assessed starting 6 months after hospital discharge. Results: Antibiotic exposure was consistently associated with a significant decrease in the risk of novel mood disorders and anxiety and stressor-related disorders in: men (mood (OR 0.84, 95% CI 0.77, 0.91), anxiety (OR 0.88, 95% CI 0.82, 0.95), women (mood (OR 0.94, 95% CI 0.89,1.00), anxiety (OR 0.93, 95% CI 0.88, 0.98), those who are 26–49 years old (mood (OR 0.87, 95% CI 0.80, 0.94), anxiety (OR 0.90, 95% CI 0.84, 0.97)), and in those ≥50 years old (mood (OR 0.91, 95% CI 0.86, 0.97), anxiety (OR 0.92, 95% CI 0.87, 0.97). Risk of intentional harm and suicidality was decreased in men (OR 0.73, 95% CI 0.55, 0.98) and in those ≥50 years old (OR 0.67, 95% CI 0.49, 0.92). Risk of psychotic disorders was also decreased in subjects ≥50 years old (OR 0.83, 95 CI: 0.69, 0.99). Conclusion: Use of antibiotics in the inpatient setting is associated with protective effects against multiple psychiatric outcomes in an age- and sex-dependent manner. | en |
| dc.description.version | Published version | en |
| dc.format.extent | 13 page(s) | en |
| dc.identifier | ARTN 1290052 (Article number) | en |
| dc.identifier.doi | https://doi.org/10.3389/fphar.2023.1290052 | en |
| dc.identifier.eissn | 1663-9812 | en |
| dc.identifier.issn | 1663-9812 | en |
| dc.identifier.orcid | Kablinger, Anita [0000-0002-7131-0036] | en |
| dc.identifier.orcid | Clinton, Sarah [0000-0001-7158-411X] | en |
| dc.identifier.orcid | Hanlon, Alexandra [0000-0002-9612-2197] | en |
| dc.identifier.other | PMC10801048 | en |
| dc.identifier.other | 1290052 (PII) | en |
| dc.identifier.pmid | 38259293 | en |
| dc.identifier.uri | https://hdl.handle.net/10919/118415 | en |
| dc.identifier.volume | 14 | en |
| dc.publisher | Frontiers | en |
| dc.relation.uri | https://www.ncbi.nlm.nih.gov/pubmed/38259293 | en |
| dc.rights | Creative Commons Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
| dc.subject | risk | en |
| dc.subject | antibiotic | en |
| dc.subject | psychosis | en |
| dc.subject | retrospective | en |
| dc.subject | suicidality | en |
| dc.subject | mood disorders | en |
| dc.subject | anxiety | en |
| dc.subject | sex | en |
| dc.title | Antibiotic exposure is associated with decreased risk of psychiatric disorders | en |
| dc.title.serial | Frontiers in Pharmacology | en |
| dc.type | Article - Refereed | en |
| dc.type.other | Article | en |
| dc.type.other | Journal | en |
| dcterms.dateAccepted | 2023-12-01 | en |
| pubs.organisational-group | /Virginia Tech | en |
| pubs.organisational-group | /Virginia Tech/Science | en |
| pubs.organisational-group | /Virginia Tech/Science/Statistics | en |
| pubs.organisational-group | /Virginia Tech/Faculty of Health Sciences | en |
| pubs.organisational-group | /Virginia Tech/All T&R Faculty | en |
| pubs.organisational-group | /Virginia Tech/Science/COS T&R Faculty | en |
| pubs.organisational-group | /Virginia Tech/Science/School of Neuroscience | en |
| pubs.organisational-group | /Virginia Tech/VT Carilion School of Medicine | en |
| pubs.organisational-group | /Virginia Tech/VT Carilion School of Medicine/Psychiatry and Behavioral Medicine | en |
| pubs.organisational-group | /Virginia Tech/VT Carilion School of Medicine/Psychiatry and Behavioral Medicine/Psychiatry and Behavioral Medicine | en |
| pubs.organisational-group | /Virginia Tech/Science/Statistics/Center for Biostatistics & Health Data Science (CBHDS) | en |
| pubs.organisational-group | /Virginia Tech/VT Carilion School of Medicine/TEACH Members | en |