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Induction of anti-ergotamine antibodies in mice and steers and protection against fescue toxicosis in mice

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dc.contributor.authorRice, Rebeccaen
dc.contributor.committeechairBlodgett, Dennisen
dc.contributor.committeecochairSchurig, Gerhardten
dc.contributor.committeememberAllen, Vivien G.en
dc.contributor.committeememberSwecker, William S.en
dc.contributor.committeememberHolladay, Steven D.en
dc.contributor.departmentVeterinary Medical Sciencesen
dc.date.accessioned2014-03-14T21:12:45Zen
dc.date.adate2008-06-06en
dc.date.available2014-03-14T21:12:45Zen
dc.date.issued1995en
dc.date.rdate2008-06-06en
dc.date.sdate2008-06-06en
dc.description.abstractTall fescue (Festuca arundinacea Schreb.) is often infected by the endophytic fungus, Acremonium coenophialum (Morgan-Jones and Gams) The fungus produces ergo peptide alkaloids, especially ergovaline. Consumption of endophyte-infected (ED fescue forage by cattle decreases serum prolactin and average daily weight gains, which results in economic losses for producers. Anecdotal reports suggest cattle with fescue toxicosis may not respond to vaccination. Hyperprolactinemia decreases cell-mediated and humoral immune responses in mice. Therefore, steers grazing EI or endophyte-free (EF) fescue forages were vaccinated to assess humoral immune responses. Steers grazing EI fescue exhibited classical clinical signs of fescue toxicosis, and mounted humoral immune responses to vaccination, despite hyperprolactinemia. Lymphocyte proliferation responses to mitogens in mice fed EI diets were similar to mice fed EF diets. Production of interferon gamma and interleukin-4 was higher by splenocytes from mice fed EI diets, whereas interleukin-2 tended to be lower. Fescue toxicosis may stimulate T helper cell 2 subset of CD4⁺ T cells. The T<sub>H</sub>2 subset may augment humoral immune responses to vaccination.en
dc.description.degreePh. D.en
dc.format.extentxv, 195 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-06062008-155524en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-06062008-155524/en
dc.identifier.urihttp://hdl.handle.net/10919/38126en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V856_1995.R534.pdfen
dc.relation.isformatofOCLC# 34346716en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectvaccinesen
dc.subjectergot alkaloidsen
dc.subjectmannich reactionen
dc.subjectcholera toxinsen
dc.subjectmicrospheresen
dc.subject.lccLD5655.V856 1995.R534en
dc.titleInduction of anti-ergotamine antibodies in mice and steers and protection against fescue toxicosis in miceen
dc.typeDissertationen
dc.type.dcmitypeTexten
thesis.degree.disciplineVeterinary Medical Sciencesen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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