Experimental determination of the oral bioavailability and bioaccessibility of lead particles

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dc.contributor.authorDeshommes, Eliseen
dc.contributor.authorTardif, Roberten
dc.contributor.authorEdwards, Marc A.en
dc.contributor.authorSauvé, Sébastienen
dc.contributor.authorPrévost, Michèleen
dc.contributor.departmentCivil and Environmental Engineeringen
dc.date.accessioned2013-01-17T16:04:58Zen
dc.date.available2013-01-17T16:04:58Zen
dc.date.issued2012-11-22en
dc.date.updated2013-01-17T16:04:59Zen
dc.description.abstractIn vivo estimations of Pb particle bioavailability are costly and variable, because of the nature of animal assays. The most feasible alternative for increasing the number of investigations carried out on Pb particle bioavailability is in vitro testing. This testing method requires calibration using in vivo data on an adapted animal model, so that the results will be valid for childhood exposure assessment. Also, the test results must be reproducible within and between laboratories. The Relative Bioaccessibility Leaching Procedure, which is calibrated with in vivo data on soils, presents the highest degree of validation and simplicity. This method could be applied to Pb particles, including those in paint and dust, and those in drinking water systems, which although relevant, have been poorly investigated up to now for childhood exposure assessment.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationChemistry Central Journal. 2012 Nov 22;6(1):138en
dc.identifier.doihttps://doi.org/10.1186/1752-153X-6-138en
dc.identifier.urihttp://hdl.handle.net/10919/19162en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderElise Deshommes et al.; licensee BioMed Central Ltd.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleExperimental determination of the oral bioavailability and bioaccessibility of lead particlesen
dc.title.serialChemistry Central Journalen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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