The Pathophysiological Changes and Clinical Effects of Tetramethylpyrazine in ICR Mice with Fluoride-Induced Hepatopathy

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dc.contributor.authorZhang, Shuaien
dc.contributor.authorZheng, Yileien
dc.contributor.authorDu, Hongen
dc.contributor.authorZhang, Weien
dc.contributor.authorLi, Haohuanen
dc.contributor.authorOu, Yangpingen
dc.contributor.authorXu, Funengen
dc.contributor.authorLin, Juchunen
dc.contributor.authorFu, Hualinen
dc.contributor.authorNi, Xueqingen
dc.contributor.authorChang, Li-Jenen
dc.contributor.authorShu, Gangen
dc.date.accessioned2023-06-27T17:28:16Zen
dc.date.available2023-06-27T17:28:16Zen
dc.date.issued2023-06-19en
dc.date.updated2023-06-27T13:22:45Zen
dc.description.abstractThe excessive intake of fluoride, one of the trace elements required to maintain health, leads to liver injury. Tetramethylpyrazine (TMP) is a kind of traditional Chinese medicine monomer with a good antioxidant and hepatoprotective function. The aim of this study was to investigate the effect of TMP on liver injury induced by acute fluorosis. A total of 60 1-month-old male ICR mice were selected. All mice were randomly divided into five groups: a control (K) group, a model (F) group, a low-dose (LT) group, a medium-dose (MT) group, and a high-dose (HT) group. The control and model groups were given distilled water, while 40 mg/kg (LT), 80 mg/kg (MT), or 160 mg/kg (HT) of TMP was fed by gavage for two weeks, with a maximum gavage volume for the mice of 0.2 mL/10 g/d. Except for the control group, all groups were given fluoride (35 mg/kg) by an intraperitoneal injection on the last day of the experiment. The results of this study showed that, compared with the model group, TMP alleviated the pathological changes in the liver induced by the fluoride and improved the ultrastructure of liver cells; TMP significantly decreased the levels of ALT, AST, and MDA (<i>p</i> &lt; 0.05) and increased the levels of T-AOC, T-SOD, and GSH (<i>p</i> &lt; 0.05). The results of mRNA detection showed that TMP significantly increased the mRNA expression levels of Nrf2, HO-1, CAT, GSH-Px, and SOD in the liver compared with the model group (<i>p</i> &lt; 0.05). In conclusion, TMP can inhibit oxidative stress by activating the Nrf2 pathway and alleviate the liver injury induced by fluoride.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationZhang, S.; Zheng, Y.; Du, H.; Zhang, W.; Li, H.; Ou, Y.; Xu, F.; Lin, J.; Fu, H.; Ni, X.; Chang, L.-J.; Shu, G. The Pathophysiological Changes and Clinical Effects of Tetramethylpyrazine in ICR Mice with Fluoride-Induced Hepatopathy. Molecules 2023, 28, 4849.en
dc.identifier.doihttps://doi.org/10.3390/molecules28124849en
dc.identifier.urihttp://hdl.handle.net/10919/115544en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectacute fluorosisen
dc.subjecttetramethylpyrazineen
dc.subjectliveren
dc.subjectoxidative damageen
dc.subjectNrf2en
dc.titleThe Pathophysiological Changes and Clinical Effects of Tetramethylpyrazine in ICR Mice with Fluoride-Induced Hepatopathyen
dc.title.serialMoleculesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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