Neurotoxicity and immunotoxicity assessment in CBA/J mice with chronic Toxoplasma gondii infection and multiple oral exposures to methylmercury

dc.contributor.authorKing, M. D.en
dc.contributor.authorLindsay, David S.en
dc.contributor.authorHolladay, Steven D.en
dc.contributor.authorEhrich, Marion F.en
dc.date.accessed2014-06-16en
dc.date.accessioned2014-06-20T14:13:17Zen
dc.date.available2014-06-20T14:13:17Zen
dc.date.issued2003-08en
dc.description.abstractThe present study was conducted to determine the effect of multiple low doses of methylmercury (MeHg) on the course of a chronic Toxoplasma gondii infection. Four groups of 6-wk-old female CBA/J mice either were fed 25 T gondii tissue cysts of the ME-49 strain or were vehicle control. Six weeks later, half of each group was orally gavaged with 8-mg/kg body weight doses of MeHg on days 0, 2, 4, 7, 10, and 13, totaling 4 experimental groups. Mice were killed on day 17 or 18 after MeHg exposure. Flow cytometric analysis of lymphocyte subpopulations in the thymus demonstrated a significant increase in the percentage of CD4(-)CD8(+) T-cells in mice exposed to MeHg with a concurrent T gondii infection. Groups of mice exposed to MeHg showed a decrease in total thymic cellularity and cellularity of all T-cell subpopulations when compared with control mice, but viability of these cells was unaffected. Splenic cell viability was decreased in mice exposed to MeHg, but alterations in T-cell subpopulations were not noted. These data indicate that multiple low doses of MeHg may not exacerbate chronic toxoplasmosis, but MeHg-induced effects on the immune system were evident.en
dc.description.sponsorshipNIH Grant F36GM20301en
dc.description.sponsorshipVirginia-Maryland Regional College of Veterinary Medicineen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMarquea D. King, David S. Lindsay, S. Holladay, and M. Ehrich (2003). "Neurotoxicity and Immunotoxicity Assessment in CBA/J Mice with Chronic Toxoplasma gondii Infection and Multiple Oral Exposures to Methylmercury," Journal of Parasitology, Vol. 89, No. 4, pp. 856-859. doi: http://dx.doi.org/10.1645/GE-79Ren
dc.identifier.doihttps://doi.org/10.1645/ge-79ren
dc.identifier.issn0022-3395en
dc.identifier.urihttp://hdl.handle.net/10919/49060en
dc.identifier.urlhttp://www.bioone.org/doi/abs/10.1645/GE-79Ren
dc.language.isoenen
dc.publisherAmerican Society of Parasitologyen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectexpressionen
dc.subjectsitesen
dc.subjectbrainen
dc.subjectparasitologyen
dc.titleNeurotoxicity and immunotoxicity assessment in CBA/J mice with chronic Toxoplasma gondii infection and multiple oral exposures to methylmercuryen
dc.title.serialJournal of Parasitologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
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