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Transport and Metabolism Behavior of Brazilein during Its Entrance into Neural Cells

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dc.contributor.authorZhao, Shuangen
dc.contributor.authorWang, Xin-Peien
dc.contributor.authorJiang, Jing-Feien
dc.contributor.authorChai, Yu-Shuangen
dc.contributor.authorTian, Yuen
dc.contributor.authorFeng, Tian-Shien
dc.contributor.authorDing, Yien
dc.contributor.authorHuang, Jingen
dc.contributor.authorLei, Fanen
dc.contributor.authorXing, Dong-Mingen
dc.contributor.authorDu, Li-Junen
dc.contributor.departmentChemistryen
dc.date.accessioned2018-10-03T18:10:24Zen
dc.date.available2018-10-03T18:10:24Zen
dc.date.issued2014-10-02en
dc.description.abstractBrazilein, a natural small molecule, shows a variety of pharmacological activities, especially on nervous system and immune system. As a potential multifunctional drug, we studied the distribution and the transport behavior and metabolic behavior of brazilein in vivo and in vitro. Brazilein was found to be able to distribute in the mouse brain and transport into neural cells. A metabolite was found in the brain and in the cells. Positive and negative mode-MS/MS and Q-TOF were used to identify the metabolite. MS/MS fragmentation mechanisms showed the methylation occurred at the10-hydroxyl of brazilein (10-O-methylbrazilein). Further, catechol-O- methyltransferase (COMT) was confirmed as a crucial enzyme correlated with the methylated metabolite generation by molecular docking and pharmacological experiment.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0108000en
dc.identifier.eissn1932-6203en
dc.identifier.issue10en
dc.identifier.othere108000en
dc.identifier.pmid25275506en
dc.identifier.urihttp://hdl.handle.net/10919/85218en
dc.identifier.volume9en
dc.language.isoenen
dc.publisherPLOSen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleTransport and Metabolism Behavior of Brazilein during Its Entrance into Neural Cellsen
dc.title.serialPLOS ONEen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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