VTechWorks staff will be away for the Thanksgiving holiday beginning at noon on Wednesday, November 27, through Friday, November 29. We will resume normal operations on Monday, December 2. Thank you for your patience.
 

Liposome-Imipramine Blue Inhibits Sonic Hedgehog Medulloblastoma In Vivo

Simple item page
dc.contributor.authorMacDonald, Tobey J.en
dc.contributor.authorLiu, Jingboen
dc.contributor.authorYu, Bingen
dc.contributor.authorMalhotra, Anshuen
dc.contributor.authorMunson, Jennifer M.en
dc.contributor.authorPark, Jaekeun C.en
dc.contributor.authorWang, Kentyen
dc.contributor.authorFei, Baoweien
dc.contributor.authorBellamkonda, Ravien
dc.contributor.authorArbiser, Jacken
dc.contributor.departmentFralin Biomedical Research Instituteen
dc.date.accessioned2021-03-15T11:43:59Zen
dc.date.available2021-03-15T11:43:59Zen
dc.date.issued2021-03-11en
dc.date.updated2021-03-12T14:40:49Zen
dc.description.abstractSonic hedgehog subtype of medulloblastoma (SHH MB) with metastasis or specific clinical or molecular alteration shas a poor prognosis and current therapy results in long-term cognitive impairment in the majority of survivors. Thus, a great need exists for new targeted therapeutic approaches to more effectively treat SHH MB in children. Imipramine blue (IB), a novel molecule with anti-tumor properties, inhibits the NADPH oxidase (NOX) family of enzymes, which are critical for SHH MB survival and treatment resistance. In this study, IB was encapsulated within a liposome to form a liposomal nanoparticle, Liposome-IB (Lipo-IB). This complex has the ability to cross the blood–brain barrier and be preferentially taken up by tumor cells within the brain. We demonstrated in vitro that Lipo-IB treatment caused a dose-dependent decrease in SHH MB cell viability and migration. Short-term administration of single agent Lipo-IB treatment of SHH MB in vivo significantly inhibited tumor growth, reduced the tumor volume, including a complete tumor response, and improved survival compared to control treated mice, without any observable toxicity. We conclude that Lipo-IB is a potential novel nanoparticle-based therapeutic for the treatment of SHH MB that warrants further preclinical safety and efficacy testing for development towards clinical investigation.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMacDonald, T.J.; Liu, J.; Yu, B.; Malhotra, A.; Munson, J.; Park, J.C.; Wang, K.; Fei, B.; Bellamkonda, R.; Arbiser, J. Liposome-Imipramine Blue Inhibits Sonic Hedgehog Medulloblastoma In Vivo. Cancers 2021, 13, 1220.en
dc.identifier.doihttps://doi.org/10.3390/cancers13061220en
dc.identifier.urihttp://hdl.handle.net/10919/102717en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectmedulloblastomaen
dc.subjectreactive oxygenen
dc.subjectNox4en
dc.subjectsonic hedghogen
dc.titleLiposome-Imipramine Blue Inhibits Sonic Hedgehog Medulloblastoma In Vivoen
dc.title.serialCancersen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
cancers-13-01220.pdf
Size:
4.97 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Journal Articles, Multidisciplinary Digital Publishing Institute (MDPI)
Destination Area: Adaptive Brain and Behavior (ABB)
Scholarly Works, Fralin Biomedical Research Institute at VTC