Studies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenes

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dc.contributor.authorMagnin, Geraldineen
dc.contributor.authorBissel, Philippeen
dc.contributor.authorCouncil-Troche, Roberto McAlisteren
dc.contributor.authorZhou, Zhiguoen
dc.contributor.authorEhrich, Marion F.en
dc.date.accessioned2020-02-06T18:02:05Zen
dc.date.available2020-02-06T18:02:05Zen
dc.date.issued2019-11-12en
dc.description.abstractIn vitro experiments previously published demonstrated the ability of fullerenes to decrease the capability of organophosphorus (OP) compounds to inhibit acetylcholinesterase. Experiments described herein demonstrate molecular level affinity interactions between fullerenes and the OP test compound paraoxon with NMR spectroscopy. The calculated binding constant of 19 M-1 indicates that this binding was not covalent.en
dc.description.notesThis work was supported by the CounterAct Program, NIH Office of the Director, NINDS grant U01NS063723. The authors have no conflicts of interest. The experimental work was done at Virginia Tech. Dr Geraldine Magnin and Dr Philippe Bissel have since relocated to Manhattan, KS (Kansas State University). Dr Zhiguo Zhou has relocated to Zymeron Corporation, Durham NC.en
dc.description.sponsorshipCounterAct Program, NIH Office of the Director, NINDS [U01NS063723]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1021/acsomega.9b02587en
dc.identifier.issn2470-1343en
dc.identifier.issue20en
dc.identifier.pmid31737826en
dc.identifier.urihttp://hdl.handle.net/10919/96746en
dc.identifier.volume4en
dc.language.isoenen
dc.rightsCreative Commons Attribution NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.titleStudies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenesen
dc.title.serialACS Omegaen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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