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Metabolic Markers Demonstrate the Heterogeneity of Myosteatosis in Community-Dwelling Older Black Men from the Health ABC Study

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dc.contributor.authorFarsijani, Samanehen
dc.contributor.authorMarron, Megan M.en
dc.contributor.authorMiljkovic, Ivaen
dc.contributor.authorBaugh, Mary Elizabethen
dc.contributor.authorKritchevsky, Stephen B.en
dc.contributor.authorNewman, Anne B.en
dc.contributor.departmentFralin Biomedical Research Instituteen
dc.date.accessioned2021-04-09T19:44:31Zen
dc.date.available2021-04-09T19:44:31Zen
dc.date.issued2021-04-07en
dc.date.updated2021-04-09T13:48:48Zen
dc.description.abstractMyosteatosis is a complex condition, associated with aging and diverse pathological conditions (e.g., diabetes), that contributes to mobility disability. Improved characterization of myosteatosis is required to develop targeted interventions to maintain muscle health in aging. We first determined the associations between plasma metabolites and intermuscular fat (IMF) in a cross-sectional analysis of 313 older Black men from Health ABC Study. Using partial correlation analysis, 34/350 metabolites were associated with IMF, the majority of which were lipids and organic acids. Next, we used Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), as an indicator of metabolic health to delineate the anthropometric, functional, and metabolic heterogeneity of myosteatosis in a case-control matching analysis. We categorized participants based on their IMF and HOMA-IR levels into: Low-IMF with Low- versus High-HOMA, as well as High-IMF with Low- versus High-HOMA. Among participants with similar levels of IMF, those who were metabolically unhealthy, i.e., with High HOMA-IR, had higher fat and lean mass, muscle strength, and had hyperglycemia, hypertriglyceridemia, hyperinsulinemia, and higher levels of plasma metabolites belonging to diacylglycerols, triacylglycerols, fatty acid and aminoacyl-tRNA biosynthesis pathways versus those with Low HOMA-IR. In summary, HOMA-IR delineates the heterogeneity of myosteatosis by distinguishing metabolically healthy versus unhealthy individuals.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationFarsijani, S.; Marron, M.M.; Miljkovic, I.; Baugh, M.E.; Kritchevsky, S.B.; Newman, A.B. Metabolic Markers Demonstrate the Heterogeneity of Myosteatosis in Community-Dwelling Older Black Men from the Health ABC Study. Metabolites 2021, 11, 224.en
dc.identifier.doihttps://doi.org/10.3390/metabo11040224en
dc.identifier.urihttp://hdl.handle.net/10919/103002en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectmyosteatosisen
dc.subjectmetabolomicsen
dc.subjectAgingen
dc.subjectheterogeneityen
dc.subjectAfrican Americanen
dc.subjectmobilityen
dc.subjectmuscleen
dc.titleMetabolic Markers Demonstrate the Heterogeneity of Myosteatosis in Community-Dwelling Older Black Men from the Health ABC Studyen
dc.title.serialMetabolitesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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Journal Articles, Multidisciplinary Digital Publishing Institute (MDPI)
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