A Scheme for Ultra-Fast Computed Tomography Based on Stationary Multi-Beam X-ray Sources
dc.contributor.author | Gong, Hao | en |
dc.contributor.committeechair | Cao, Guohua | en |
dc.contributor.committeemember | Zhu, Yizheng | en |
dc.contributor.committeemember | LaConte, Stephen M. | en |
dc.contributor.committeemember | Wyatt, Chris L. | en |
dc.contributor.committeemember | Wang, Ge | en |
dc.contributor.department | Biomedical Engineering | en |
dc.date.accessioned | 2017-02-17T09:00:17Z | en |
dc.date.available | 2017-02-17T09:00:17Z | en |
dc.date.issued | 2017-02-16 | en |
dc.description.abstract | The current cardiac computed tomography (CT) technology is mainly limited by motion blurring and radiation dose. The conceptual multi-source interior CT scheme has provided a potential solution to reduce motion artifacts and radiation exposure. This dissertation work conducted multi-facet investigations on a novel multi-source interior CT architecture (G. Cao, et. al, IEEE Access, 2014;2:1263-71) which employs distributed stationary multi-beam Carbon-nanotube (CNT) X-ray sources and simultaneously operates multiple source-detector chains to improve temporal resolution. The collimation based interior CT is integrated in each imaging chain, to suppress radiation dose. The central thesis statement is: Compared to conventional CT design, this distributed source array based multi-source interior CT architecture shall provide ultra-fast CT scan of region-of-interest (ROI) inside body with comparable image quality at lower radiation dose. Comprehensive studies were conducted to separately investigate three critical aspects of multi-source interior CT: interior CT mode, X-ray scattering, and scatter correction methods. First, a single CNT X-ray source based interior micro-CT was constructed to serve as a down-scaled experimental verification platform for interior CT mode. Interior CT mode demonstrated comparable contrast-noise-ratio (CNR) and image structural similarity to the standard global CT mode, while inducing a significant radiation dose reduction (< 83.9%). Second, the data acquisition of multi-source interior CT was demonstrated at clinical geometry, via numerical simulation and physical experiments. The simultaneously operated source-detector chains induced significant X-ray forward / cross scattering and thus caused severe CNR reduction (< 68.5%) and CT number error (< 1122 HU). To address the scatter artifacts, a stationary beam-stopper-array (BSA) based and a source-trigger-sequence (STS) based scatter correction methods were proposed to enable the online scatter measurement / correction with further radiation dose reduction (< 50%). Moreover, a deterministic physics model was also developed to iteratively remove the scatter-artifacts in the multi-source interior CT, without the need for modifications in imaging hardware or protocols. The three proposed scatter correction methods improved CNR (< 94.0%) and suppressed CT number error (< 48 HU). With the dedicated scatter correction methods, the multi-source interior CT could provide ROI-oriented imaging with acceptable image quality at significantly reduced radiation dose. | en |
dc.description.degree | Ph. D. | en |
dc.format.medium | ETD | en |
dc.identifier.other | vt_gsexam:9743 | en |
dc.identifier.uri | http://hdl.handle.net/10919/75054 | en |
dc.publisher | Virginia Tech | en |
dc.rights | In Copyright | en |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | en |
dc.subject | Multi-source | en |
dc.subject | computed tomography | en |
dc.subject | scatter correction | en |
dc.subject | temporal resolution | en |
dc.subject | interior tomography | en |
dc.title | A Scheme for Ultra-Fast Computed Tomography Based on Stationary Multi-Beam X-ray Sources | en |
dc.type | Dissertation | en |
thesis.degree.discipline | Biomedical Engineering | en |
thesis.degree.grantor | Virginia Polytechnic Institute and State University | en |
thesis.degree.level | doctoral | en |
thesis.degree.name | Ph. D. | en |
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