Blood and Cerebrospinal Fluid α-Tocopherol and Selenium Concentrations in Neonatal Foals with Neuroaxonal Dystrophy

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dc.contributor.authorFinno, C. J.en
dc.contributor.authorEstell, Kristaen
dc.contributor.authorKatzman, S.en
dc.contributor.authorWinfield, L.en
dc.contributor.authorRendahl, A.en
dc.contributor.authorTextor, J.en
dc.contributor.authorBannasch, D. L.en
dc.contributor.authorPuschner, B.en
dc.coverage.spatialUnited Statesen
dc.date.accessioned2017-05-09T19:59:11Zen
dc.date.available2017-05-09T19:59:11Zen
dc.date.issued2015-11en
dc.description.abstractBACKGROUND: Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (NAD/EDM) is a neurodegenerative disorder affecting genetically predisposed foals maintained on α-tocopherol (α-TP)-deficient diet. OBJECTIVE: Intramuscular α-TP and selenium (Se) administration at 4 days of age would have no significant effect on serum or cerebrospinal fluid (CSF) α-TP in healthy foals. Serum and CSF α-TP, but not Se, would be significantly decreased in NAD/EDM-affected foals during first year of life. ANIMALS: Fourteen Quarter horse foals; 10 healthy foals supplemented with 0.02 mL/kg injectable α-TP and Se (n = 5) or saline (n = 5) at 4 days of age and 4 unsupplemented NAD/EDM-affected foals. METHODS: Complete neurologic examinations were performed, blood and CSF were collected before (4 days of age) and after supplementation at 10, 30, 60, 120, 180, 240, and 360 days of age. Additional blood collections occurred at 90, 150, 210, and 300 days. At 540 days, NAD/EDM-affected foals and 1 unsupplemented healthy foal were euthanized and necropsies performed. RESULTS: Significant decreases in blood, CSF α-TP and Se found in the first year of life in all foals, with most significant changes in serum α-TP from 4-150 days. Dam α-TP and Se significantly influenced blood concentrations in foals. Injection of α-TP and Se did not significantly increase CSF Se, blood or CSF α-TP in healthy foals. NAD/EDM-affected foals had significantly lower CSF α-TP through 120 days. CONCLUSIONS AND CLINICAL IMPORTANCE: Injection of α-TP and Se at 4 days of age does not significantly increase blood or CSF α-TP. Despite all 14 foals remaining deficient in α-TP, only the 4 genetically predisposed foals developed NAD/EDM.en
dc.description.versionPublished versionen
dc.format.extent1667 - 1675 page(s)en
dc.identifier.doihttps://doi.org/10.1111/jvim.13618en
dc.identifier.eissn1939-1676en
dc.identifier.issue6en
dc.identifier.orcidEstell, KE [0000-0002-9321-1952]en
dc.identifier.urihttp://hdl.handle.net/10919/77598en
dc.identifier.volume29en
dc.languageengen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/26391904en
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.holderThe Author(s)en
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectAtaxiaen
dc.subjectEquineen
dc.subjectGeneticsen
dc.subjectVitamin Een
dc.subjectAnimalsen
dc.subjectAnimals, Newbornen
dc.subjectFemaleen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectHorse Diseasesen
dc.subjectHorsesen
dc.subjectMaleen
dc.subjectNeuroaxonal Dystrophiesen
dc.subjectSeleniumen
dc.subjectalpha-Tocopherolen
dc.titleBlood and Cerebrospinal Fluid α-Tocopherol and Selenium Concentrations in Neonatal Foals with Neuroaxonal Dystrophyen
dc.title.serialJournal of Veterinary Internal Medicineen
dc.typeArticle - Refereeden
dc.type.otherResearch Support, N.I.H., Extramuralen
dc.type.otherResearch Support, Non-U.S. Gov'ten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Equine Medical Centeren

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