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New tools for the study of virus-vector interactions in mosquitoes

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dc.contributor.authorWiley, Michael R.en
dc.contributor.committeecochairMyles, Kevin M.en
dc.contributor.committeecochairAdelman, Zachary N.en
dc.contributor.committeememberHelm, Richard F.en
dc.contributor.committeememberPaulson, Sally L.en
dc.contributor.committeememberRoberts, Paul C.en
dc.contributor.departmentEntomologyen
dc.date.accessioned2017-04-06T15:45:06Zen
dc.date.adate2012-03-06en
dc.date.available2017-04-06T15:45:06Zen
dc.date.issued2012-01-16en
dc.date.rdate2016-10-18en
dc.date.sdate2012-01-25en
dc.description.abstractMosquito-borne diseases continue to be a burden to global health. The viruses that cause these diseases are maintained in nature through a biological transmission cycle involving susceptible vertebrate and mosquito hosts. While knowledge of the interactions occurring between mosquito-borne viruses and vertebrates is considerable, much less is known about the interactions of these viruses with their disease vectors. Studies with Drosophila melanogaster have been important in understanding how insects respond to viral infections. However, mosquitoes and the viruses they vector have co-evolved during a long period of time. Unfortunately, many of the genetic advantages of a fly model are not available when working with mosquitoes. Nevertheless, a sequenced genome, and molecular tools such as high-throughput sequencing and RNAi knockdown are helping to bridge these gaps. Here we describe several additional tools for the study of virus-vector interactions in the mosquito.en
dc.description.degreePh. D.en
dc.identifier.otheretd-01252012-184010en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-01252012-184010/en
dc.identifier.urihttp://hdl.handle.net/10919/77343en
dc.language.isoen_USen
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectIRESen
dc.subjectB2en
dc.subjectRNA-based immunityen
dc.subjectalphavirusen
dc.subjectmosquitoen
dc.titleNew tools for the study of virus-vector interactions in mosquitoesen
dc.typeDissertationen
dc.type.dcmitypeTexten
thesis.degree.disciplineEntomologyen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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